7P46 | pdb_00007p46

Crystal Structure of Xanthomonas campestris Tryptophan 2,3-dioxygenase (TDO)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trp_dioxygenase	e7p46A1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
B	Trp_dioxygenase	e7p46B1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
C	Trp_dioxygenase	e7p46C1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
D	Trp_dioxygenase	e7p46D1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
E	Trp_dioxygenase	e7p46E1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
F	Trp_dioxygenase	e7p46F1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
G	Trp_dioxygenase	e7p46G1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
H	Trp_dioxygenase	e7p46H1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF03301	Tryptophan 2,3-dioxygenase (Trp_dioxygenase)	Tryptophan 2,3-dioxygenase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Tryptophan 2,3-dioxygenase	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity L-tryptophan 2,3-dioxygenase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	catabolic process oxoacid metabolic process aromatic amino acid family catabolic process indole-containing compound metabolic process amino acid metabolic process organic acid catabolic process organic acid metabolic process acetyl-CoA metabolic process alpha-amino acid metabolic process nucleobase-containing compound metabolic process acyl-CoA metabolic process L-tryptophan metabolic process carboxylic acid catabolic process nucleobase-containing small molecule metabolic process amide catabolic process catabolic process oxoacid metabolic process aromatic amino acid family catabolic process indole-containing compound metabolic process amino acid metabolic process organic acid catabolic process organic acid metabolic process acetyl-CoA metabolic process alpha-amino acid metabolic process nucleobase-containing compound metabolic process acyl-CoA metabolic process L-tryptophan metabolic process carboxylic acid catabolic process nucleobase-containing small molecule metabolic process amide catabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process amide metabolic process phosphorus metabolic process amino acid catabolic process nucleoside phosphate metabolic process aromatic amino acid metabolic process L-amino acid catabolic process carboxylic acid metabolic process primary metabolic process L-tryptophan catabolic process L-amino acid metabolic process purine-containing compound metabolic process proteinogenic amino acid metabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process indole-containing compound catabolic process L-tryptophan catabolic process to acetyl-CoA organophosphate metabolic process metabolic process cellular process small molecule catabolic process ketone metabolic process non-proteinogenic amino acid metabolic process L-tryptophan catabolic process to kynurenine benzene-containing compound metabolic process kynurenine metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR004981	Tryptophan 2,3-dioxygenase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR037217	Tryptophan/Indoleamine 2,3-dioxygenase-like	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.