8GSW | pdb_00008gsw

Crystal structure of human cardiac alpha actin A108G mutant (AMPPNP state) in complex with fragmin F1 domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e8gswA1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00626	Gelsolin repeat (Gelsolin)	Gelsolin repeat		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Actin, alpha cardiac muscle 1	hydrolase activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding hydrolase activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding protein binding myosin binding polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity microfilament motor activity macromolecular conformation isomerase activity ATP-dependent activity	developmental process mesenchyme migration multicellular organismal process mesenchyme morphogenesis animal organ development mesenchyme development tissue development tissue morphogenesis anatomical structure morphogenesis tissue migration anatomical structure development animal organ morphogenesis heart development cardiac muscle tissue development developmental process mesenchyme migration multicellular organismal process mesenchyme morphogenesis animal organ development mesenchyme development tissue development tissue morphogenesis anatomical structure morphogenesis tissue migration anatomical structure development animal organ morphogenesis heart development cardiac muscle tissue development heart morphogenesis muscle tissue morphogenesis striated muscle tissue development circulatory system development muscle structure development multicellular organism development cardiac muscle tissue morphogenesis muscle organ development muscle tissue development muscle organ morphogenesis system development regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process cellular developmental process cellular component assembly involved in morphogenesis skeletal myofibril assembly cell development membraneless organelle assembly muscle cell differentiation cellular component organization cellular component biogenesis striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation actin filament-based process cellular component organization or biogenesis skeletal muscle thin filament assembly actin cytoskeleton organization actomyosin structure organization organelle assembly actin filament organization organelle organization myofibril assembly anatomical structure formation involved in morphogenesis striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization actin-mediated cell contraction actin filament-based movement actin-myosin filament sliding heart process system process circulatory system process heart contraction blood circulation cardiac muscle cell development cardiac cell development cardiac muscle cell differentiation cardiocyte differentiation cardiac myofibril assembly	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol synapse glutamatergic synapse blood microparticle sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex polymeric cytoskeletal fiber actin filament cell body I band actin-based cell projection filopodium
B	Actin-binding protein fragmin P	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cation binding ion binding metal ion binding small molecule binding	cellular component organization actin polymerization or depolymerization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization	cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020902	Actin/actin-like conserved site	Conserved Site
A	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A	IPR004001	Actin, conserved site	Conserved Site
A	IPR004000	Actin family	Family
B	IPR007123	Gelsolin-like domain	Domain
B	IPR007122	Villin/Gelsolin	Family
B	IPR029006	ADF-H/Gelsolin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P68032	atrial septal defect 5 hypertrophic cardiomyopathy 11 left ventricular noncompaction dilated cardiomyopathy hypertrophic cardiomyopathy dilated cardiomyopathy 1R cardiomyopathy gastric cancer large cell medulloblastoma limb-girdle muscular dystrophy Ametropia medulloblastoma psoriasis restrictive cardiomyopathy dilated cardiomyopathy 1A atrial septal defect 5 hypertrophic cardiomyopathy 11 left ventricular noncompaction dilated cardiomyopathy hypertrophic cardiomyopathy dilated cardiomyopathy 1R cardiomyopathy gastric cancer large cell medulloblastoma limb-girdle muscular dystrophy Ametropia medulloblastoma psoriasis restrictive cardiomyopathy dilated cardiomyopathy 1A Emery-Dreifuss muscular dystrophy familial hypertrophic cardiomyopathy gastric neoplasm malignant glioma amyotrophic lateral sclerosis myopathy Becker muscular dystrophy precancerous condition refractive error facioscapulohumeral muscular dystrophy familial isolated dilated cardiomyopathy hereditary diffuse gastric adenocarcinoma juvenile dermatomyositis atrial septal defect osteosarcoma Charcot-Marie-Tooth disease Duchenne muscular dystrophy familial dilated cardiomyopathy

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	HIC	Parent Component: HIS RESID: AA0317 PSI-MOD : 1'-methyl-L-histidine MOD:00322

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.