8KBL | pdb_00008kbl

Structure of AcrIIA7 complexed with 1',3'-cADPR and cGG

External Resource: Annotation


Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF11195Thoeris anti-defense 2-like domain (Tad2-like)Thoeris anti-defense 2-like domainThis entry represents Thoeris anti-defense 2 from Bacillus phage SP01 (Tad2) and similar sequences from tailed bacteriophages and bacterial prophages. Tad2 is an anti-defence protein that counteracts the host Thoeris antiviral defence system. It sequ ...This entry represents Thoeris anti-defense 2 from Bacillus phage SP01 (Tad2) and similar sequences from tailed bacteriophages and bacterial prophages. Tad2 is an anti-defence protein that counteracts the host Thoeris antiviral defence system. It sequesters the immune signalling molecules produced by Thoeris TIR-domain proteins in response to phage infection [1]. This entry also includes AcrIIA7 Cas9 inhibitor protein gene.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Inhibitor of Type II CRISPR-Cas system - -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR021361Thoeris anti-defense 2-like domainDomain