8T55 | pdb_00008t55

Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	WD repeat-containing protein 91	enzyme regulator activity molecular function regulator activity phosphatidylinositol 3-kinase regulator activity kinase regulator activity phosphatidylinositol 3-kinase inhibitor activity	cellular response to stimulus regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation negative regulation of signal transduction regulation of response to stimulus regulation of cell communication cellular process phosphatidylinositol 3-kinase/protein kinase B signal transduction catabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process protein metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process cellular localization transport intracellular transport establishment of localization vesicle-mediated transport endosomal transport vesicle-mediated transport between endosomal compartments localization early endosome to late endosome transport establishment of localization in cell	membrane-bounded organelle endosome membrane intracellular anatomical structure early endosome endosome membrane intracellular vesicle early endosome membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle membrane bounding membrane of organelle membrane-bounded organelle endosome membrane intracellular anatomical structure early endosome endosome membrane intracellular vesicle early endosome membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle cytoplasm vesicle organelle membrane cytosol late endosome membrane late endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR056327	ARMC9, CTLH-like domain	Domain
A, B, C	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, B, C	IPR039724	WD repeat-containing protein 91	Family
A, B, C	IPR001680	WD40 repeat	Repeat
A, B, C	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: A4D1P6	B-cell chronic lymphocytic leukemia osteosarcoma malignant ependymoma nasopharyngeal carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.