8TBP | pdb_00008tbp

HLA-DRB1*15:01 in complex with smith antigen

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054671	3000071	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8040455	3000521	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054671	3000071	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	MHC antigen-recognition domain	8040455	3000521	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	MHC antigen-recognition domain	8055636	3000521	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054705	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054703	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	MHC antigen-recognition domain	8034737	3000521	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054705	3000071	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054703	3000071	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	MHC antigen-recognition domain	8034737	3000521	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	MHC antigen-recognition domain	8055636	3000521	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Source
A, C	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	Domain
A, C	PF00993	Class II histocompatibility antigen, alpha domain (MHC_II_alpha)	Class II histocompatibility antigen, alpha domain	Domain
B, D	PF00969	Class II histocompatibility antigen, beta domain (MHC_II_beta)	Class II histocompatibility antigen, beta domain	Domain
B, D	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	HLA class II histocompatibility antigen, DR alpha chain	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity MHC class II receptor activity immune receptor activity polysaccharide binding carbohydrate binding binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity MHC class II receptor activity immune receptor activity polysaccharide binding carbohydrate binding protein binding signaling receptor binding T cell receptor binding	multicellular organismal process regulation of cellular process regulation of alpha-beta T cell activation regulation of leukocyte activation positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion multicellular organismal process regulation of cellular process regulation of alpha-beta T cell activation regulation of leukocyte activation positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation CD4-positive, alpha-beta T cell activation positive regulation of leukocyte activation alpha-beta T cell activation regulation of immune system process regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of immune system process positive regulation of cellular process regulation of biological process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion cell activation biological regulation regulation of T cell activation positive regulation of alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell activation immune system process regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process cellular process regulation of lymphocyte activation response to stimulus immune response positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus regulation of immune response antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of endogenous peptide antigen via MHC class II antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen adaptive immune response antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of exogenous antigen system process nervous system process cognition peptide antigen assembly with MHC class II protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class II protein complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex assembly MHC protein complex assembly cellular component organization or biogenesis dendritic cell antigen processing and presentation myeloid dendritic cell antigen processing and presentation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of immune effector process T cell mediated immunity positive regulation of leukocyte mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of leukocyte mediated cytotoxicity leukocyte mediated immunity positive regulation of immune effector process positive regulation of adaptive immune response regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of adaptive immune response regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity regulation of cell killing positive regulation of cell killing cell killing regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation cell activation involved in immune response regulation of cell development CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response multicellular organism development cell differentiation regulation of T-helper cell differentiation anatomical structure development T cell differentiation developmental process T-helper cell differentiation leukocyte differentiation cellular developmental process regulation of developmental process cell development regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation regulation of T cell differentiation alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response leukocyte activation involved in immune response lymphocyte activation involved in immune response regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis T cell differentiation involved in immune response regulation of hemopoiesis immunological memory formation process positive regulation of T cell differentiation positive regulation of developmental process positive regulation of memory T cell differentiation positive regulation of cell development memory T cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of memory T cell differentiation immunological memory process positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of regulatory T cell differentiation regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulation of regulatory T cell differentiation CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulatory T cell differentiation	membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell surface MHC protein complex cell periphery MHC class II protein complex protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex endosome membrane endosome late endosome membrane endomembrane system late endosome lytic vacuole vacuole lysosome organelle subcompartment lumenal side of endoplasmic reticulum membrane side of membrane lumenal side of membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane immunological synapse vacuolar membrane lytic vacuole membrane lysosomal membrane Golgi membrane Golgi apparatus early endosome early endosome membrane autolysosome autolysosome membrane secondary lysosome Golgi apparatus subcompartment trans-Golgi network membrane trans-Golgi network transport vesicle transport vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane
B, D	HLA class II histocompatibility antigen, DRB1 beta chain	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding polysaccharide binding carbohydrate binding protein binding signaling receptor binding T cell receptor binding molecular transducer activity transmembrane signaling receptor activity binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding polysaccharide binding carbohydrate binding protein binding signaling receptor binding T cell receptor binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity MHC class II receptor activity immune receptor activity CD4 receptor binding structural constituent of cytoskeleton structural molecule activity	antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune system process antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein tetramerization antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune system process antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to other organism response to external stimulus detection of biotic stimulus detection of bacterium response to biotic stimulus detection of stimulus response to bacterium detection of other organism response to external biotic stimulus negative regulation of lymphocyte proliferation multicellular organismal process regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of immune system process regulation of leukocyte proliferation regulation of biological process cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion negative regulation of cellular process regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion biological regulation cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation positive regulation of phosphorylation regulation of catalytic activity positive regulation of biological process positive regulation of phosphate metabolic process regulation of transferase activity positive regulation of metabolic process positive regulation of molecular function regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of cellular process positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation positive regulation of catalytic activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of phosphorus metabolic process metabolic process regulation of phosphorylation regulation of metabolic process defense response immune response response to stress inflammatory response inflammatory response to antigenic stimulus myeloid leukocyte differentiation regulation of leukocyte differentiation positive regulation of monocyte differentiation cellular developmental process regulation of developmental process cell development regulation of cell differentiation mononuclear cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of cell differentiation positive regulation of hemopoiesis cell differentiation anatomical structure development monocyte differentiation positive regulation of immune system process developmental process regulation of multicellular organismal development regulation of monocyte differentiation hemopoiesis regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process positive regulation of leukocyte differentiation leukocyte differentiation regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response regulation of response to stress negative regulation of inflammatory response to antigenic stimulus negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of response to external stimulus negative regulation of defense response regulation of immune response regulation of type II interferon production type II interferon production cytokine production regulation of cytokine production negative regulation of type II interferon production negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of interleukin-4 production interleukin-4 production positive regulation of viral life cycle positive regulation of viral process viral life cycle modulation by symbiont of entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of viral entry into host cell regulation of viral life cycle regulation of viral process symbiont entry into host cell viral process symbiont entry into host positive regulation of viral entry into host cell positive regulation by symbiont of entry into host regulation of biological process involved in symbiotic interaction adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of immune effector process T cell mediated immunity positive regulation of leukocyte mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of response to stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune response positive regulation of leukocyte mediated cytotoxicity leukocyte mediated immunity positive regulation of immune effector process positive regulation of adaptive immune response regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of adaptive immune response regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity adaptive immune response immune effector process regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity regulation of cell killing positive regulation of cell killing cell killing regulation of alpha-beta T cell activation lymphocyte differentiation positive regulation of T cell differentiation positive regulation of cell activation positive regulation of leukocyte activation alpha-beta T cell activation T cell differentiation positive regulation of T cell activation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of regulatory T cell differentiation positive regulation of alpha-beta T cell activation regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of leukocyte cell-cell adhesion regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation positive regulation of CD4-positive, alpha-beta T cell activation alpha-beta T cell differentiation CD4-positive, alpha-beta T cell activation regulation of lymphocyte differentiation positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of cell adhesion regulation of regulatory T cell differentiation CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulation of CD4-positive, alpha-beta T cell activation regulatory T cell differentiation positive regulation of lymphocyte differentiation cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction signaling regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling immune response-regulating cell surface receptor signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway T cell receptor signaling pathway antigen receptor-mediated signaling pathway activation of immune response positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade humoral immune response epidermis development tissue development antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of exogenous antigen interleukin-10 production regulation of interleukin-10 production peptide antigen assembly with MHC class II protein complex peptide antigen assembly with MHC protein complex MHC class II protein complex assembly MHC protein complex assembly protein localization regulation of localization establishment of protein localization nitrogen compound transport positive regulation of establishment of protein localization localization carbohydrate homeostasis cellular macromolecule localization establishment of localization in cell positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion establishment of localization cellular response to oxygen-containing compound regulation of protein secretion regulation of secretion cellular response to carbohydrate stimulus chemical homeostasis response to glucose response to chemical glucose homeostasis positive regulation of protein localization insulin secretion involved in cellular response to glucose stimulus cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport homeostatic process positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion regulation of secretion by cell secretion by cell positive regulation of hormone secretion response to monosaccharide response to carbohydrate positive regulation of secretion amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus positive regulation of peptide secretion regulation of transport secretion regulation of peptide transport regulation of establishment of protein localization export from cell cell-cell signaling response to oxygen-containing compound cellular response to glucose stimulus regulation of protein transport positive regulation of protein secretion peptide transport response to hexose cellular response to chemical stimulus cellular homeostasis positive regulation of transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport insulin secretion macrophage differentiation regulation of response to biotic stimulus positive regulation of response to biotic stimulus immune response to tumor cell regulation of response to tumor cell T cell mediated immune response to tumor cell regulation of T cell mediated immune response to tumor cell response to tumor cell positive regulation of immune response to tumor cell regulation of immune response to tumor cell positive regulation of T cell mediated immune response to tumor cell positive regulation of response to tumor cell T-helper 1 type immune response positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription dendritic cell antigen processing and presentation myeloid dendritic cell antigen processing and presentation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process protein metabolic process positive regulation of protein phosphorylation protein modification process protein phosphorylation regulation of protein metabolic process macromolecule modification cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response regulation of T-helper cell differentiation T-helper cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response leukocyte activation involved in immune response lymphocyte activation involved in immune response T cell differentiation involved in immune response immunological memory formation process positive regulation of memory T cell differentiation memory T cell differentiation regulation of memory T cell differentiation immunological memory process	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle endosome membrane endosome late endosome membrane endomembrane system late endosome vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi membrane Golgi apparatus transport vesicle transport vesicle membrane polymeric cytoskeletal fiber intracellular membraneless organelle intermediate filament cytoskeleton cytoskeleton membraneless organelle intermediate filament supramolecular fiber supramolecular polymer supramolecular complex MHC protein complex MHC class II protein complex protein-containing complex plasma membrane protein complex membrane protein complex organelle subcompartment lumenal side of endoplasmic reticulum membrane lumenal side of membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane immunological synapse autolysosome autolysosome membrane secondary lysosome Golgi apparatus subcompartment trans-Golgi network membrane trans-Golgi network COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane
E, F	Small nuclear ribonucleoprotein-associated protein N peptide	ribonucleoprotein complex binding snRNP binding protein-containing complex binding binding RNA binding nucleic acid binding	RNA splicing RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process biosynthetic process metabolic process cellular process RNA processing RNA splicing RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle U4 snRNP cellular anatomical structure small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle U4 snRNP cellular anatomical structure small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex U5 snRNP cytoplasm U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U2-type spliceosomal complex prespliceosome U2-type prespliceosome U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, C	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
A, C	IPR003597	Immunoglobulin C1-set	Domain
A, C	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A, C	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A, C	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
A, C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, C	IPR007110	Immunoglobulin-like domain	Domain
A, C	IPR001003	MHC class II, alpha chain, N-terminal	Domain
B, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, D	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
B, D	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
B, D	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
B, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, D	IPR007110	Immunoglobulin-like domain	Domain
B, D	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
B, D	IPR003597	Immunoglobulin C1-set	Domain
B, D	IPR000353	MHC class II, beta chain, N-terminal	Domain
E, F	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
E, F	IPR017131	Small ribonucleoprotein associated, SmB/SmN	Family
E, F	IPR047575	Sm domain	Domain
E, F	IPR010920	LSM domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P01903	toxic shock syndrome lung carcinoma multiple sclerosis juvenile dermatomyositis systemic sclerosis ulcerative colitis Parkinson disease Sjogren syndrome Crohn disease Graham Little Piccardi Lassueur syndrome pancreatic ductal adenocarcinoma Hashimoto thyroiditis pilocytic astrocytoma Hodgkins lymphoma psoriatic arthritis toxic shock syndrome lung carcinoma multiple sclerosis juvenile dermatomyositis systemic sclerosis ulcerative colitis Parkinson disease Sjogren syndrome Crohn disease Graham Little Piccardi Lassueur syndrome pancreatic ductal adenocarcinoma Hashimoto thyroiditis pilocytic astrocytoma Hodgkins lymphoma psoriatic arthritis invasive ductal breast carcinoma skin basal cell carcinoma adrenal cortex carcinoma limb-girdle muscular dystrophy systemic lupus erythematosus astrocytic tumor Becker muscular dystrophy malignant glioma celiac disease dermatomyositis neoplasm of mature B-cells Down syndrome non-alcoholic fatty liver disease esophageal adenocarcinoma osteoporosis Graham Little-Piccardi-Lassueur syndrome pancreatic intraductal papillary-mucinous carcinoma head and neck cancer primary biliary cholangitis IgA glomerulonephritis squamous cell lung carcinoma lung adenocarcinoma atopic eczema lymphoplasmacytic lymphoma breast cancer marginal zone lymphoma chronic obstructive pulmonary disease diabetes mellitus nephrotic syndrome Duchenne muscular dystrophy non-small cell lung carcinoma glioblastoma ovarian cancer Graves disease heart disease prostate carcinoma interstitial cystitis juvenile idiopathic arthritis subependymal giant cell astrocytoma alopecia areata lung cancer temporal arteritis vitiligo autism spectrum disorder malignant ependymoma breast carcinoma membranous glomerulonephritis myasthenia gravis diffuse scleroderma nodular sclerosis classical Hodgkin lymphoma osteoarthritis
B, D	Pharos: P01911	Crohn disease narcolepsy rheumatoid arthritis sarcoidosis ulcerative colitis juvenile idiopathic arthritis nephrotic syndrome membranous glomerulonephritis psoriatic arthritis Hashimoto thyroiditis asthma pancreatitis follicular lymphoma chronic beryllium disease multiple sclerosis Crohn disease narcolepsy rheumatoid arthritis sarcoidosis ulcerative colitis juvenile idiopathic arthritis nephrotic syndrome membranous glomerulonephritis psoriatic arthritis Hashimoto thyroiditis asthma pancreatitis follicular lymphoma chronic beryllium disease multiple sclerosis angioedema type 1 diabetes mellitus oropharynx cancer eosinophilia-myalgia syndrome systemic lupus erythematosus typhoid fever visceral leishmaniasis alopecia areata lung carcinoma allergic disease urticaria limited scleroderma proteinuria Graves disease schizophrenia narcolepsy-cataplexy syndrome drug allergy bullous pemphigoid Lymphoma, Intermediate-Grade cerebrovascular disorder reticulum cell sarcoma metabolic syndrome X colorectal adenoma hepatitis B virus infection multiple sclerosis, susceptibility to 1 sinusitis acquired metabolic disease squamous cell carcinoma nasal cavity disease diabetes mellitus hypothyroidism neoplasm of oropharynx temporal arteritis IgA glomerulonephritis autism spectrum disorder nodular sclerosis classical Hodgkin lymphoma diffuse scleroderma B-cell chronic lymphocytic leukemia oral cavity cancer vitiligo bipolar disorder endogenous depression lymphoma C1 inhibitor deficiency primary biliary cholangitis eosinophilic granulomatosis with polyangiitis cervical cancer lymphosarcoma head and neck cancer colorectal cancer sarcoidosis, susceptibility to, 1 hepatitis C virus infection myasthenia gravis Crohn's colitis Sjogren syndrome hepatocellular carcinoma narcolepsy without cataplexy cutaneous lupus erythematosus squamous cell lung carcinoma Hodgkins lymphoma nasopharyngeal disease systemic sclerosis idiopathic membranous glomerulonephritis atopic eczema diffuse cutaneous systemic sclerosis ileocolitis non-alcoholic fatty liver disease pemphigus vulgaris celiac disease esophageal adenocarcinoma chronic obstructive pulmonary disease rosacea head and neck squamous cell carcinoma CREST syndrome myositis skin basal cell carcinoma allergic rhinitis demyelinating disease arthritic joint disease neoplasm of mature B-cells Takayasu arteritis idiopathic pulmonary fibrosis autism neuromyelitis optica inflammatory bowel disease autoimmune disease non-Hodgkin lymphoma leprosy osteoporosis drug-induced liver injury Lyme disease peripheral arterial disease
E, F	Pharos: P63162	Prader-Willi syndrome Angelman syndrome Autistic Disorder lung cancer malignant mesothelioma pancreatic intraductal papillary-mucinous carcinoma atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm autism large cell medulloblastoma malignant glioma ovarian cancer Prader-Willi syndrome Angelman syndrome Autistic Disorder lung cancer malignant mesothelioma pancreatic intraductal papillary-mucinous carcinoma atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm autism large cell medulloblastoma malignant glioma ovarian cancer plasma cell myeloma subependymal giant cell astrocytoma