8ZIO | pdb_00008zio

Crystal structure of the methyltransferase PsiM in complex with SAH and Psilocybin

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05971	RNA methyltransferase (Methyltransf_10)	RNA methyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Psilocybin synthase	transferase activity, transferring one-carbon groups 4-hydroxytryptamine 4-phosphate methyltransferase activity transferase activity methyltransferase activity catalytic activity	alkaloid biosynthetic process oxoacid metabolic process indole alkaloid metabolic process indole-containing compound metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process secondary metabolic process mycotoxin metabolic process secondary metabolite biosynthetic process L-tryptophan metabolic process indole-containing compound biosynthetic process indolalkylamine metabolic process phosphate-containing compound metabolic process psilocybin biosynthetic process alkaloid biosynthetic process oxoacid metabolic process indole alkaloid metabolic process indole-containing compound metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process secondary metabolic process mycotoxin metabolic process secondary metabolite biosynthetic process L-tryptophan metabolic process indole-containing compound biosynthetic process indolalkylamine metabolic process phosphate-containing compound metabolic process psilocybin biosynthetic process indole alkaloid biosynthetic process small molecule metabolic process phosphorus metabolic process toxin metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process aromatic amino acid metabolic process mycotoxin biosynthetic process carboxylic acid metabolic process alkaloid metabolic process primary metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process amine metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process metabolic process cellular process toxin biosynthetic process biogenic amine metabolic process ribonucleoprotein complex biogenesis rRNA methylation RNA metabolic process rRNA processing rRNA modification nucleobase-containing compound metabolic process cellular component biogenesis RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process macromolecule methylation RNA modification methylation macromolecule modification macromolecule metabolic process rRNA base methylation RNA methylation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR010286	METTL16/RlmF family	Family
A	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A	IPR017182	Methyltransferase METTL16/PsiM	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.