Annotations: 9B4S

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Ras-like P-loop GTPases	8019657	3002022	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00794	PI3-kinase family, ras-binding domain (PI3K_rbd)	PI3-kinase family, ras-binding domain	Certain members of the PI3K family possess Ras-binding domains in their N-termini. These regions show some similarity (although not highly significant similarity) to Ras-binding Pfam:PF00788 domains (unpublished observation).	Domain
A	PF00454	Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)	Phosphatidylinositol 3- and 4-kinase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity histone H3S57 kinase activity phosphatidylinositol kinase activity lipid kinase activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity enzyme regulator activity molecular function activator activity protein kinase regulator activity kinase activator activity enzyme activator activity molecular function regulator activity protein kinase activator activity kinase regulator activity histone H4S1 kinase activity histone H4 kinase activity histone H3T11 kinase activity histone H3S28 kinase activity histone H2B kinase activity histone H2BS36 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity histone H2AS121 kinase activity histone H2A kinase activity protein binding insulin receptor substrate binding AMP-activated protein kinase activity 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity histone H3T45 kinase activity eukaryotic translation initiation factor 2alpha kinase activity histone H3T3 kinase activity histone H2BS14 kinase activity Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity protein serine kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2AS1 kinase activity	endothelial cell migration cell migration cellular process cell motility cellular response to stimulus regulation of biological process regulation of cellular process cellular response to growth factor stimulus cell surface receptor signaling pathway response to stimulus signaling response to endogenous stimulus biological regulation cell surface receptor protein tyrosine kinase signaling pathway endothelial cell migration cell migration cellular process cell motility cellular response to stimulus regulation of biological process regulation of cellular process cellular response to growth factor stimulus cell surface receptor signaling pathway response to stimulus signaling response to endogenous stimulus biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication vascular endothelial growth factor signaling pathway cellular response to endogenous stimulus cellular response to vascular endothelial growth factor stimulus signal transduction response to growth factor enzyme-linked receptor protein signaling pathway negative regulation of programmed cell death regulation of apoptotic process regulation of anoikis negative regulation of biological process regulation of programmed cell death cell death negative regulation of anoikis negative regulation of apoptotic process anoikis negative regulation of cellular process apoptotic process programmed cell death insulin-like growth factor receptor signaling pathway fibroblast apoptotic process negative regulation of fibroblast apoptotic process regulation of fibroblast apoptotic process regulation of multicellular organism growth developmental process multicellular organismal process regulation of growth regulation of developmental growth regulation of developmental process developmental growth growth multicellular organism growth regulation of multicellular organismal process intracellular signal transduction phosphatidylinositol-mediated signaling regulation of body fluid levels wound healing cell activation hemostasis blood coagulation response to stress coagulation regulation of biological quality response to wounding platelet activation response to ketone response to lipid response to glucocorticoid response to oxygen-containing compound response to corticosteroid response to hormone response to steroid hormone response to chemical response to dexamethasone cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation positive regulation of biological process smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation positive regulation of cellular process multicellular organism development anatomical structure development vasculature development system development circulatory system development connective tissue development adipose tissue development animal organ development tissue development homeostatic process cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus response to activity multicellular organismal-level homeostasis energy homeostasis cellular response to acid chemical response to water cellular response to chemical stress cellular response to environmental stimulus response to acid chemical cellular response to hydrostatic pressure cellular response to stress cellular response to water stimulus response to hydrostatic pressure response to abiotic stimulus cellular response to abiotic stimulus sexual reproduction cellular developmental process reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation cellular component organization cell differentiation chromatin organization chromatin remodeling cellular component organization or biogenesis regulation of biosynthetic process epigenetic programming of gene expression epigenetic regulation of gene expression multicellular organismal reproductive process regulation of macromolecule metabolic process gene expression genomic imprinting macromolecule biosynthetic process regulation of gene expression autosome genomic imprinting biosynthetic process germ cell development regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cellular response to hormone stimulus cellular response to peptide hormone stimulus response to nitrogen compound response to insulin cellular response to insulin stimulus heart process system process circulatory system process cardiac muscle contraction heart contraction muscle contraction muscle system process blood circulation striated muscle contraction cardiac muscle cell contraction actin filament-based movement actin filament-based process actin-mediated cell contraction negative regulation of metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process regulation of cellular component organization positive regulation of cellular component organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly regulation of lamellipodium assembly regulation of lamellipodium organization positive regulation of cell projection organization lamellipodium assembly plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly positive regulation of lamellipodium assembly regulation of cellular component biogenesis positive regulation of lamellipodium organization regulation of plasma membrane bounded cell projection assembly lamellipodium organization cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process localization import into cell transport phagocytosis endocytosis establishment of localization vesicle-mediated transport positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling TOR signaling regulation of signaling regulation of TOR signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling regulation of cytoskeleton organization regulation of actin filament organization regulation of actin filament-based process actin cytoskeleton organization actin filament organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization response to muscle inactivity response to inactivity protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to membrane localization within membrane protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization positive regulation of protein localization regulation of protein localization to membrane monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process glucose metabolic process ERBB signaling pathway epidermal growth factor receptor signaling pathway regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation positive regulation of leukocyte activation regulation of immune system process regulation of cell-cell adhesion positive regulation of immune system process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation immune system process lymphocyte costimulation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process T cell costimulation regulation of lymphocyte activation hepaticobiliary system development gland development liver development relaxation of cardiac muscle relaxation of muscle immune response-regulating cell surface receptor signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response immune response-activating cell surface receptor signaling pathway immune response T cell receptor signaling pathway regulation of immune response antigen receptor-mediated signaling pathway activation of immune response blood vessel morphogenesis tube development angiogenesis anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction response to butyrate response to fatty acid negative regulation of catabolic process catabolic process macroautophagy autophagy regulation of catabolic process regulation of autophagy negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy process utilizing autophagic mechanism regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process regulation of cellular component size protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization negative regulation of protein-containing complex disassembly negative regulation of supramolecular fiber organization cellular component disassembly actin polymerization or depolymerization negative regulation of cellular component organization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization negative regulation of protein depolymerization negative regulation of organelle organization regulation of actin filament length negative regulation of actin filament depolymerization protein depolymerization regulation of anatomical structure size cellular respiration energy derivation by oxidation of organic compounds regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy regulation of cellular respiration response to mechanical stimulus response to external stimulus response to muscle stretch response to amino acid response to L-leucine	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex membrane phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex membrane phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane cell-cell junction intercalated disc anchoring junction cell junction cell-cell contact zone cell periphery plasma membrane cell projection cell leading edge plasma membrane bounded cell projection lamellipodium perinuclear region of cytoplasm phosphatidylinositol 3-kinase complex, class IB
B	Ras-related protein R-Ras2	guanyl nucleotide binding binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding guanyl nucleotide binding binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding GTP binding purine ribonucleoside triphosphate binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	developmental process multicellular organismal process cellular developmental process glial cell migration nervous system development Schwann cell migration neurogenesis multicellular organism development gliogenesis cell differentiation anatomical structure development cellular process cell migration cell motility developmental process multicellular organismal process cellular developmental process glial cell migration nervous system development Schwann cell migration neurogenesis multicellular organism development gliogenesis cell differentiation anatomical structure development cellular process cell migration cell motility system development ossification osteoblast differentiation positive regulation of locomotion regulation of cell motility regulation of cellular process positive regulation of biological process regulation of Schwann cell migration regulation of glial cell migration positive regulation of cell migration positive regulation of Schwann cell migration positive regulation of cell motility regulation of cell migration locomotion positive regulation of cellular process regulation of biological process biological regulation positive regulation of glial cell migration regulation of locomotion cellular response to stimulus small GTPase-mediated signal transduction response to stimulus signaling Ras protein signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane membrane-bounded organelle Golgi membrane intracellular anatomical structure Golgi apparatus intracellular membrane-bounded organelle endomembrane system intracellular organelle bounding membrane of organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane membrane-bounded organelle Golgi membrane intracellular anatomical structure Golgi apparatus intracellular membrane-bounded organelle endomembrane system intracellular organelle bounding membrane of organelle organelle cytoplasm organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015433	Phosphatidylinositol kinase	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR037704	PI3Kalpha, catalytic domain	Domain
A	IPR002420	C2 phosphatidylinositol 3-kinase-type domain	Domain
A	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	Conserved Site
A	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	Homologous Superfamily
A	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Homologous Superfamily
A	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	Domain
A	IPR003113	Phosphatidylinositol 3-kinase, adaptor-binding domain	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR035892	C2 domain superfamily	Homologous Superfamily
B	IPR005225	Small GTP-binding domain	Domain
B	IPR020849	Small GTPase, Ras-type	Family
B	IPR001806	Small GTPase	Family
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P42336	seborrheic keratosis squamous cell carcinoma ovarian cancer CLOVES syndrome Cowden disease colorectal cancer Cowden syndrome 5 renal cell carcinoma megalencephaly-capillary malformation-polymicrogyria syndrome nevus, epidermal cancer head and neck squamous cell carcinoma diffuse large B-cell lymphoma nasopharyngeal carcinoma esophageal adenocarcinoma seborrheic keratosis squamous cell carcinoma ovarian cancer CLOVES syndrome Cowden disease colorectal cancer Cowden syndrome 5 renal cell carcinoma megalencephaly-capillary malformation-polymicrogyria syndrome nevus, epidermal cancer head and neck squamous cell carcinoma diffuse large B-cell lymphoma nasopharyngeal carcinoma esophageal adenocarcinoma hepatocellular carcinoma skin basal cell carcinoma lung cancer papillary renal cell carcinoma adenocarcinoma salivary gland adenoid cystic carcinoma Mouth Neoplasms hyperplasia gastric cancer prostate cancer sarcoma hereditary diffuse gastric adenocarcinoma adenoid cystic carcinoma breast adenocarcinoma tubular adenocarcinoma breast carcinoma chromophobe renal cell carcinoma collecting duct carcinoma penile neoplasm granular cell carcinoma sarcomatoid renal cell carcinoma spindle cell sarcoma breast cancer clear cell renal carcinoma ovarian disease gastric neoplasm colon carcinoma glioblastoma colorectal carcinoma polydactyly head and neck neoplasm psoriasis hepatoblastoma hereditary breast carcinoma cutaneous melanoma schizophrenia skin pigmented basal cell carcinoma angioosteohypertrophic syndrome benign neoplasm of stomach endometriosis thyroid gland carcinoma invasive ductal breast carcinoma epithelioid sarcoma uterine disease large cell medulloblastoma non-small cell lung carcinoma fetal alcohol spectrum disorder lung adenocarcinoma cholangiocarcinoma lung carcinoma ovarian epithelial tumor genetic endocrine growth disease Lynch syndrome colorectal adenocarcinoma penile cancer glioma head and neck cancer renal carcinoma cribriform carcinoma megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 atypical teratoid rhabdoid tumor IgA glomerulonephritis inverted follicular keratosis liver cancer cerebral cortical dysplasia oral cavity neoplasm fetal alcohol syndrome lung benign neoplasm ovarian carcinoma gastric carcinoma lung disease ovarian neoplasm head and neck carcinoma hemimegalencephaly cribriform carcinoma of breast hereditary hemorrhagic telangiectasia adult hepatocellular carcinoma melanoma digestive system disease hydrocephalus B-cell chronic lymphocytic leukemia ductal breast carcinoma in situ stomach carcinoma in situ intellectual disability urinary bladder cancer juvenile dermatomyositis breast disease familial prostate carcinoma cerebrovascular disorder oral cavity squamous cell carcinoma follicular lymphoma
B	Pharos: P62070	ovarian cancer juvenile myelomonocytic leukemia Liver Neoplasms, Experimental B-cell chronic lymphocytic leukemia hereditary breast carcinoma ovarian neoplasm breast cancer invasive ductal breast carcinoma malignant mesothelioma spina bifida cancer ovarian carcinoma ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.