Annotations: 9DYB

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF12895	Anaphase-promoting complex, cyclosome, subunit 3 (ANAPC3)	Anaphase-promoting complex, cyclosome, subunit 3	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	E3 ubiquitin-protein ligase CHIP	SMAD binding protein binding binding R-SMAD binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity SMAD binding protein binding binding R-SMAD binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity misfolded protein binding heat shock protein binding protein-folding chaperone binding protein-macromolecule adaptor activity molecular adaptor activity cytoskeletal protein binding tau protein binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding Hsp90 protein binding Hsp70 protein binding kinase binding identical protein binding protein homodimerization activity protein dimerization activity TPR domain binding protein domain specific binding signaling receptor binding G protein-coupled receptor binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process ERAD pathway regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process ERAD pathway cellular response to stress response to chemical response to stress proteolysis cellular process metabolic process protein metabolic process macromolecule metabolic process response to endoplasmic reticulum stress response to ischemia response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to oxygen levels response to abiotic stimulus cellular response to heat response to heat response to temperature stimulus protein autoubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of proteasomal protein catabolic process regulation of cellular process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction regulation of hormone metabolic process regulation of hormone levels steroid metabolic process regulation of steroid metabolic process regulation of lipid metabolic process hormone metabolic process glucocorticoid metabolic process regulation of glucocorticoid metabolic process lipid metabolic process protein polyubiquitination negative regulation of transforming growth factor beta receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus negative regulation of signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus negative regulation of cellular process enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA damage response DNA repair regulation of cellular component organization positive regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of chaperone-mediated protein complex assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly chaperone-mediated protein complex assembly protein-containing complex assembly cellular component organization or biogenesis positive regulation of chaperone-mediated protein complex assembly intracellular receptor signaling pathway negative regulation of intracellular signal transduction regulation of intracellular signal transduction peroxisome proliferator activated receptor signaling pathway regulation of peroxisome proliferator activated receptor signaling pathway nuclear receptor-mediated signaling pathway negative regulation of peroxisome proliferator activated receptor signaling pathway muscle hypertrophy regulation of muscle adaptation multicellular organismal process system process negative regulation of muscle hypertrophy regulation of system process striated muscle hypertrophy regulation of muscle system process muscle system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy muscle adaptation cardiac muscle hypertrophy regulation of multicellular organismal process negative regulation of multicellular organismal process negative regulation of cardiac muscle hypertrophy cellular response to misfolded protein response to misfolded protein cellular response to topologically incorrect protein response to topologically incorrect protein autophagy chaperone-mediated autophagy process utilizing autophagic mechanism protein monoubiquitination endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein vascular associated smooth muscle contraction regulation of vascular associated smooth muscle contraction negative regulation of vasoconstriction negative regulation of muscle contraction circulatory system process smooth muscle contraction regulation of smooth muscle contraction blood vessel diameter maintenance negative regulation of smooth muscle contraction blood circulation regulation of tube diameter regulation of tube size negative regulation of vascular associated smooth muscle contraction muscle contraction regulation of blood circulation regulation of muscle contraction vascular process in circulatory system regulation of vasoconstriction vasoconstriction regulation of anatomical structure size regulation of protein modification process regulation of protein ubiquitination positive regulation of post-translational protein modification positive regulation of protein modification process regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of post-translational protein modification ERBB2 signaling pathway cell surface receptor protein tyrosine kinase signaling pathway ERBB signaling pathway positive regulation of programmed cell death positive regulation of smooth muscle cell apoptotic process muscle cell apoptotic process smooth muscle cell apoptotic process regulation of apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process positive regulation of apoptotic process positive regulation of muscle cell apoptotic process apoptotic process programmed cell death protein K63-linked ubiquitination macroautophagy regulation of autophagy positive regulation of autophagy of mitochondrion mitophagy regulation of autophagy of mitochondrion positive regulation of macroautophagy positive regulation of autophagy positive regulation of mitophagy regulation of mitophagy regulation of macroautophagy autophagy of mitochondrion protein quality control for misfolded or incompletely synthesized proteins negative regulation of programmed cell death negative regulation of smooth muscle cell apoptotic process negative regulation of apoptotic process negative regulation of muscle cell apoptotic process regulation of cellular response to stress regulation of ERAD pathway positive regulation of ERAD pathway regulation of response to endoplasmic reticulum stress positive regulation of response to stimulus positive regulation of response to endoplasmic reticulum stress regulation of response to stress	intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cytosol protein-containing complex protein folding chaperone complex intracellular protein-containing complex membrane-bounded organelle inclusion body nucleus intracellular membrane-bounded organelle nuclear inclusion body ubiquitin ligase complex catalytic complex transferase complex mitochondrion membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen ubiquitin conjugating enzyme complex endoplasmic reticulum endomembrane system
B	Heat shock 70 kDa protein 1A	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019734	Tetratricopeptide repeat	Repeat
A	IPR003613	U-box domain	Domain
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR045202	CHIP , U-box domain	Domain
A	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A	IPR041312	CHIP, N-terminal tetratricopeptide repeat domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UNE7	autosomal recessive spinocerebellar ataxia 16 autosomal dominant cerebellar ataxia spinocerebellar ataxia type 6 Ataxias, Hereditary cancer diabetes mellitus medulloblastoma primitive neuroectodermal tumor spinocerebellar ataxia type 4 spinocerebellar ataxia type 7 attention deficit hyperactivity disorder, inattentive type cerebellar ataxia intellectual disability neurodegenerative disease spinocerebellar ataxia type 1 autosomal recessive spinocerebellar ataxia 16 autosomal dominant cerebellar ataxia spinocerebellar ataxia type 6 Ataxias, Hereditary cancer diabetes mellitus medulloblastoma primitive neuroectodermal tumor spinocerebellar ataxia type 4 spinocerebellar ataxia type 7 attention deficit hyperactivity disorder, inattentive type cerebellar ataxia intellectual disability neurodegenerative disease spinocerebellar ataxia type 1 spinocerebellar ataxia type 5 atypical teratoid rhabdoid tumor bone disease large cell medulloblastoma ovarian cancer spinocerebellar ataxia type 2

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	TPO	Parent Component: THR RESID: AA0038 PSI-MOD : O-phospho-L-threonine MOD:00047

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.