Annotations: 9EZR

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	NAD(P)H dehydrogenase [quinone] 1	oxidoreductase activity NAD(P)H dehydrogenase (quinone) activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NADH dehydrogenase (quinone) (non-electrogenic) activity NADH dehydrogenase activity cytochrome-b5 reductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor NADPH dehydrogenase activity NADPH dehydrogenase (quinone) activity RNA binding binding nucleic acid binding oxidoreductase activity NAD(P)H dehydrogenase (quinone) activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NADH dehydrogenase (quinone) (non-electrogenic) activity NADH dehydrogenase activity cytochrome-b5 reductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor NADPH dehydrogenase activity NADPH dehydrogenase (quinone) activity RNA binding binding nucleic acid binding identical protein binding protein binding	vitamin E metabolic process metabolic process cellular process cellular response to stimulus response to stimulus cellular response to oxidative stress detoxification reactive oxygen species metabolic process cellular response to chemical stress response to superoxide cellular oxidant detoxification cellular response to oxygen radical cellular response to reactive oxygen species cellular response to stress vitamin E metabolic process metabolic process cellular process cellular response to stimulus response to stimulus cellular response to oxidative stress detoxification reactive oxygen species metabolic process cellular response to chemical stress response to superoxide cellular oxidant detoxification cellular response to oxygen radical cellular response to reactive oxygen species cellular response to stress response to stress cellular detoxification response to oxygen-containing compound cellular response to oxygen-containing compound response to reactive oxygen species response to toxic substance removal of superoxide radicals superoxide metabolic process response to oxidative stress cellular response to chemical stimulus response to chemical cellular response to superoxide cellular response to toxic substance response to oxygen radical ketone metabolic process ubiquinone metabolic process quinone metabolic process biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus catabolic process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process negative regulation of ferroptosis regulation of biological process regulation of cellular process negative regulation of programmed cell death biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of cellular process regulation of ferroptosis ferroptosis programmed cell death protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular response to xenobiotic stimulus xenobiotic metabolic process response to xenobiotic stimulus cell redox homeostasis cellular homeostasis homeostatic process negative regulation of protein catabolic process regulation of primary metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of macromolecule metabolic process regulation of catabolic process regulation of metabolic process regulation of protein catabolic process trans-synaptic signaling signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling synaptic transmission, cholinergic response to lipid response to lipopolysaccharide response to bacterium response to molecule of bacterial origin vitamin K metabolic process nitric oxide metabolic process nitric oxide biosynthetic process biosynthetic process reactive nitrogen species metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol synapse cell junction membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003680	Flavodoxin-like fold	Domain
A, B, C, D	IPR029039	Flavoprotein-like superfamily	Homologous Superfamily
A, B, C, D	IPR051545	NAD(P)H dehydrogenase (quinone)	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P15559	non-small cell lung carcinoma hemolytic-uremic syndrome spinocerebellar ataxia type 17 cancer plasma cell myeloma myeloid leukemia contact dermatitis papilloma liver disease chronic monocytic leukemia urinary bladder cancer Neoplasms, Experimental obesity disorder breast cancer squamous papilloma non-small cell lung carcinoma hemolytic-uremic syndrome spinocerebellar ataxia type 17 cancer plasma cell myeloma myeloid leukemia contact dermatitis papilloma liver disease chronic monocytic leukemia urinary bladder cancer Neoplasms, Experimental obesity disorder breast cancer squamous papilloma hyperglycemia kidney disease Parkinson disease asthma prostate cancer breast carcinoma cholestasis colorectal cancer diabetes mellitus osteoarthritis pancreatic intraductal papillary-mucinous carcinoma acute kidney failure plantar fibromatosis alcohol withdrawal astrocytic tumor lung cancer benign neoplasm subependymal giant cell astrocytoma myopathy colorectal carcinoma endometriosis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma papillomatosis large cell medulloblastoma attention deficit hyperactivity disorder, inattentive type psoriasis childhood acute lymphoblastic leukemia chronic obstructive pulmonary disease nasopharyngeal carcinoma urinary bladder neoplasm cutaneous lupus erythematosus diastrophic dysplasia head and neck cancer pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell neoplasm lung adenocarcinoma atypical teratoid rhabdoid tumor malignant pancreatic neoplasm schizophrenia medulloblastoma myeloid neoplasm toxic encephalopathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.