9FIC | pdb_00009fic

High-resolution X-ray structure of human PC1/3 (PCSK1) prodomain R77A,R80A,R81A triple-mutant

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16470	Peptidase S8 pro-domain (S8_pro-domain)	Peptidase S8 pro-domain	This domain is the pro-domain of several peptidases belonging to family S8 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Neuroendocrine convertase 1	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity identical protein binding protein binding binding	peptide biosynthetic process biosynthetic process metabolic process cellular process peptide metabolic process peptide hormone processing regulation of hormone levels biological regulation signaling receptor ligand precursor processing primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process protein maturation peptide biosynthetic process biosynthetic process metabolic process cellular process peptide metabolic process peptide hormone processing regulation of hormone levels biological regulation signaling receptor ligand precursor processing primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process protein maturation insulin processing proteolysis protein processing protein metabolic process macromolecule metabolic process amide metabolic process regulation of biological quality insulin metabolic process regulation of biological process signaling cell-cell signaling cell communication	cellular anatomical structure membrane membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle cellular anatomical structure membrane membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle transport vesicle extracellular region extracellular space cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR023828	Peptidase S8, subtilisin, Ser-active site	Active Site
A	IPR022398	Peptidase S8, subtilisin, His-active site	Active Site
A	IPR032815	Peptidase S8, pro-domain	Domain
A	IPR034182	Kexin/furin catalytic domain	Domain
A	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A	IPR002884	P domain	Domain
A	IPR000209	Peptidase S8/S53 domain	Domain
A	IPR015500	Peptidase S8, subtilisin-related	Family
A	IPR036852	Peptidase S8/S53 domain superfamily	Homologous Superfamily
A	IPR022005	Prohormone convertase enzyme	Domain
A	IPR023827	Peptidase S8, subtilisin, Asp-active site	Active Site
A	IPR038466	Peptidase S8, pro-domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P29120	obesity disorder obesity due to prohormone convertase I deficiency Body Weight oligodendroglioma psoriasis acquired metabolic disease atypical teratoid rhabdoid tumor Down syndrome lung cancer malignant mesothelioma Parkinson disease ulcerative colitis Alzheimer disease breast fibroadenoma glioblastoma obesity disorder obesity due to prohormone convertase I deficiency Body Weight oligodendroglioma psoriasis acquired metabolic disease atypical teratoid rhabdoid tumor Down syndrome lung cancer malignant mesothelioma Parkinson disease ulcerative colitis Alzheimer disease breast fibroadenoma glioblastoma lung carcinoma malignant pancreatic neoplasm Pick disease astrocytic tumor Crohn disease interstitial cystitis malignant ependymoma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.