9FNO | pdb_00009fno

Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Globin-like	8039836	3000554	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Globin-like	8039838	3000554	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00042	Globin (Globin)	Globin		Domain
B	PF00042	Globin (Globin)	Globin		Domain
D	PF00089	Trypsin (Trypsin)	Trypsin		Domain
E, F, G	PF00530	Scavenger receptor cysteine-rich domain (SRCR)	Scavenger receptor cysteine-rich domain	These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Hemopressin	oxygen binding binding small molecule binding oxygen carrier activity molecular carrier activity tetrapyrrole binding heme binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding	catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process oxygen transport localization transport gas transport establishment of localization one-carbon compound transport carbon dioxide transport nitric oxide transport catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process oxygen transport localization transport gas transport establishment of localization one-carbon compound transport carbon dioxide transport nitric oxide transport nitrogen compound transport response to hydrogen peroxide response to oxidative stress response to stimulus response to stress response to chemical response to oxygen-containing compound response to reactive oxygen species cellular response to stimulus cellular detoxification cellular response to chemical stimulus detoxification cellular oxidant detoxification cellular response to toxic substance response to toxic substance	protein-containing complex cellular anatomical structure intracellular anatomical structure hemoglobin complex cytoplasm cytosol haptoglobin-hemoglobin complex membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle protein-containing complex cellular anatomical structure intracellular anatomical structure hemoglobin complex cytoplasm cytosol haptoglobin-hemoglobin complex membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular vesicle membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen endocytic vesicle lumen endocytic vesicle
B	Spinorphin	hemoglobin binding protein binding binding oxygen binding small molecule binding hemoglobin alpha binding oxygen carrier activity molecular carrier activity tetrapyrrole binding heme binding cation binding ion binding metal ion binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process hydrogen peroxide catabolic process multicellular organismal process system process circulatory system process regulation of blood pressure regulation of biological quality blood circulation regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation response to wounding platelet activation oxygen transport localization transport gas transport establishment of localization one-carbon compound transport carbon dioxide transport renal system process renal absorption nitric oxide transport nitrogen compound transport regulation of tube diameter regulation of tube size vascular process in circulatory system blood vessel diameter maintenance regulation of anatomical structure size response to hydrogen peroxide response to oxidative stress response to chemical response to oxygen-containing compound response to reactive oxygen species cellular response to stimulus cellular detoxification cellular response to chemical stimulus detoxification cellular oxidant detoxification cellular response to toxic substance response to toxic substance	protein-containing complex cellular anatomical structure intracellular anatomical structure hemoglobin complex cytoplasm cytosol haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space protein-containing complex cellular anatomical structure intracellular anatomical structure hemoglobin complex cytoplasm cytosol haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle blood microparticle tertiary granule lumen tertiary granule endocytic vesicle lumen endocytic vesicle
C	Isoform 2 of Haptoglobin alpha chain	antioxidant activity hemoglobin binding protein binding binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process negative regulation of metabolic process biological regulation reactive oxygen species metabolic process hydrogen peroxide metabolic process negative regulation of biological process regulation of catabolic process regulation of hydrogen peroxide catabolic process negative regulation of reactive oxygen species metabolic process negative regulation of hydrogen peroxide metabolic process regulation of hydrogen peroxide metabolic process negative regulation of cellular process negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process negative regulation of metabolic process biological regulation reactive oxygen species metabolic process hydrogen peroxide metabolic process negative regulation of biological process regulation of catabolic process regulation of hydrogen peroxide catabolic process negative regulation of reactive oxygen species metabolic process negative regulation of hydrogen peroxide metabolic process regulation of hydrogen peroxide metabolic process negative regulation of cellular process metabolic process cellular process hydrogen peroxide catabolic process negative regulation of hydrogen peroxide catabolic process regulation of metabolic process regulation of reactive oxygen species metabolic process regulation of molecular function regulation of catalytic activity negative regulation of oxidoreductase activity negative regulation of molecular function negative regulation of catalytic activity regulation of oxidoreductase activity biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus immune system process acute-phase response inflammatory response acute inflammatory response response to hydrogen peroxide response to oxidative stress response to chemical response to oxygen-containing compound response to reactive oxygen species zymogen activation primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing protein metabolic process macromolecule metabolic process	protein-containing complex haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular anatomical structure protein-containing complex haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle secretory granule secretory vesicle cytoplasm vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule endocytic vesicle lumen endocytic vesicle
D	Haptoglobin beta chain	antioxidant activity hemoglobin binding protein binding binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process negative regulation of metabolic process biological regulation reactive oxygen species metabolic process hydrogen peroxide metabolic process negative regulation of biological process regulation of catabolic process regulation of hydrogen peroxide catabolic process negative regulation of reactive oxygen species metabolic process negative regulation of hydrogen peroxide metabolic process regulation of hydrogen peroxide metabolic process negative regulation of cellular process negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process negative regulation of metabolic process biological regulation reactive oxygen species metabolic process hydrogen peroxide metabolic process negative regulation of biological process regulation of catabolic process regulation of hydrogen peroxide catabolic process negative regulation of reactive oxygen species metabolic process negative regulation of hydrogen peroxide metabolic process regulation of hydrogen peroxide metabolic process negative regulation of cellular process metabolic process cellular process hydrogen peroxide catabolic process negative regulation of hydrogen peroxide catabolic process regulation of metabolic process regulation of reactive oxygen species metabolic process regulation of molecular function regulation of catalytic activity negative regulation of oxidoreductase activity negative regulation of molecular function negative regulation of catalytic activity regulation of oxidoreductase activity biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus immune system process acute-phase response inflammatory response acute inflammatory response response to hydrogen peroxide response to oxidative stress response to chemical response to oxygen-containing compound response to reactive oxygen species zymogen activation primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing protein metabolic process macromolecule metabolic process	protein-containing complex haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular anatomical structure protein-containing complex haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle secretory granule secretory vesicle cytoplasm vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule endocytic vesicle lumen endocytic vesicle
E, F, G	Scavenger receptor cysteine-rich type 1 protein M130	scaffold protein binding protein binding binding cargo receptor activity scavenger receptor activity	acute-phase response response to stimulus defense response response to stress inflammatory response acute inflammatory response	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane vesicle organelle membrane endocytic vesicle cell periphery plasma membrane cell surface external side of plasma membrane side of membrane extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002338	Hemoglobin, alpha-type	Family
A	IPR002339	Hemoglobin, pi	Family
A	IPR009050	Globin-like superfamily	Homologous Superfamily
A	IPR012292	Globin/Protoglobin	Homologous Superfamily
A	IPR000971	Globin	Domain
A	IPR050056	Hemoglobin and related oxygen transporters	Family
B	IPR009050	Globin-like superfamily	Homologous Superfamily
B	IPR012292	Globin/Protoglobin	Homologous Superfamily
B	IPR000971	Globin	Domain
B	IPR050056	Hemoglobin and related oxygen transporters	Family
B	IPR002337	Hemoglobin, beta-type	Family
C	IPR000436	Sushi/SCR/CCP domain	Domain
C	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
C	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
C	IPR001314	Peptidase S1A, chymotrypsin family	Family
C	IPR001254	Serine proteases, trypsin domain	Domain
C	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
D	IPR000436	Sushi/SCR/CCP domain	Domain
D	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
D	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
D	IPR001314	Peptidase S1A, chymotrypsin family	Family
D	IPR001254	Serine proteases, trypsin domain	Domain
D	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
E, F, G	IPR036772	SRCR-like domain superfamily	Homologous Superfamily
E, F, G	IPR001190	SRCR domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P69905	alpha thalassemia Heinz body anemia acquired polycythemia vera methemoglobinemia hemoglobin H disease polycythemia familial hemolytic anemia alpha thalassemia-intellectual disability syndrome type 1 sarcomatoid carcinoma carcinoma Mammary Neoplasms, Experimental type 2 diabetes mellitus cerebral infarction hemolytic anemia inborn carbohydrate metabolic disorder alpha thalassemia Heinz body anemia acquired polycythemia vera methemoglobinemia hemoglobin H disease polycythemia familial hemolytic anemia alpha thalassemia-intellectual disability syndrome type 1 sarcomatoid carcinoma carcinoma Mammary Neoplasms, Experimental type 2 diabetes mellitus cerebral infarction hemolytic anemia inborn carbohydrate metabolic disorder mammary neoplasms, animal thalassemia congenital anemia facioscapulohumeral muscular dystrophy familial polycythemia hydrops fetalis lung adenocarcinoma beta thalassemia sickle cell anemia Hb Bart's hydrops fetalis hemoglobin M disease maturity-onset diabetes of the young breast carcinoma undifferentiated carcinoma diabetes mellitus
B	Pharos: P68871	sickle cell anemia beta thalassemia dominant beta-thalassemia Heinz body anemia polycythemia methemoglobinemia alpha thalassemia echinococcosis acquired polycythemia vera malaria hemoglobin C disease Plasmodium falciparum malaria Cyanosis hemoglobin D disease inherited hemoglobinopathy sickle cell anemia beta thalassemia dominant beta-thalassemia Heinz body anemia polycythemia methemoglobinemia alpha thalassemia echinococcosis acquired polycythemia vera malaria hemoglobin C disease Plasmodium falciparum malaria Cyanosis hemoglobin D disease inherited hemoglobinopathy congenital dyserythropoietic anemia familial hemolytic anemia hemoglobin E disease beta-thalassemia HBB/LCRB hemoglobin E-beta-thalassemia syndrome juvenile dermatomyositis lung adenocarcinoma delta-beta-thalassemia lymphoplasmacytic lymphoma malignant ependymoma MALT lymphoma myopathy anemia gastric cancer pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia hemoglobin M disease beta-thalassemia major hereditary persistence of fetal hemoglobin cerebrovascular disorder sickle cell-hemoglobin E disease syndrome large cell medulloblastoma thalassemia minor lung cancer diabetes mellitus Duchenne muscular dystrophy malignant glioma medulloblastoma acute myeloid leukemia non-small cell lung carcinoma gastric carcinoma pancreatic intraductal papillary-mucinous carcinoma B-cell chronic lymphocytic leukemia periodontitis hemolytic anemia breast cancer hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome sickle cell-hemoglobin c disease syndrome invasive ductal breast carcinoma thalassemia limb-girdle muscular dystrophy tuberculosis lung carcinoma malignant colon neoplasm ductal breast carcinoma in situ malignant pancreatic neoplasm exocrine pancreatic carcinoma familial polycythemia ovarian cancer atopic eczema head and neck cancer hemoglobin C-beta-thalassemia syndrome pancreatic intraductal papillary-mucinous neoplasm beta-thalassemia intermedia hepatocellular carcinoma breast carcinoma hypophosphatemic bone disease sickle cell-hemoglobin d disease syndrome congenital anemia
C	Pharos: P00738	anemia hereditary hemochromatosis sickle cell anemia malaria tuberculosis arthritic joint disease retinal detachment breast carcinoma chronic hepatitis B virus infection type 2 diabetes mellitus diabetic peripheral angiopathy Dyslipidemias myocardial infarction anhaptoglobinemia hepatitis B virus infection anemia hereditary hemochromatosis sickle cell anemia malaria tuberculosis arthritic joint disease retinal detachment breast carcinoma chronic hepatitis B virus infection type 2 diabetes mellitus diabetic peripheral angiopathy Dyslipidemias myocardial infarction anhaptoglobinemia hepatitis B virus infection autoimmune disease leukemia allergic disease atherosclerosis HIV infectious disease schizophrenia hypertensive disorder cardiovascular disease type 1 diabetes mellitus lung adenocarcinoma major depressive disorder MALT lymphoma maturity-onset diabetes of the young acute kidney failure osteosarcoma heart disease pituitary cancer atypical teratoid rhabdoid tumor depressive disorder lung cancer female reproductive organ cancer ovarian cancer hypertension, pregnancy-induced sinusitis interstitial cystitis chronic hepatitis C virus infection lung carcinoma female reproductive system neoplasm non-small cell lung carcinoma arteriosclerosis disorder breast cancer thrombocytopenia
D	Pharos: P00738	anemia hereditary hemochromatosis sickle cell anemia malaria tuberculosis arthritic joint disease retinal detachment breast carcinoma chronic hepatitis B virus infection type 2 diabetes mellitus diabetic peripheral angiopathy Dyslipidemias myocardial infarction anhaptoglobinemia hepatitis B virus infection anemia hereditary hemochromatosis sickle cell anemia malaria tuberculosis arthritic joint disease retinal detachment breast carcinoma chronic hepatitis B virus infection type 2 diabetes mellitus diabetic peripheral angiopathy Dyslipidemias myocardial infarction anhaptoglobinemia hepatitis B virus infection autoimmune disease leukemia allergic disease atherosclerosis HIV infectious disease schizophrenia hypertensive disorder cardiovascular disease type 1 diabetes mellitus lung adenocarcinoma major depressive disorder MALT lymphoma maturity-onset diabetes of the young acute kidney failure osteosarcoma heart disease pituitary cancer atypical teratoid rhabdoid tumor depressive disorder lung cancer female reproductive organ cancer ovarian cancer hypertension, pregnancy-induced sinusitis interstitial cystitis chronic hepatitis C virus infection lung carcinoma female reproductive system neoplasm non-small cell lung carcinoma arteriosclerosis disorder breast cancer thrombocytopenia
E, F, G	Pharos: Q86VB7	IgA glomerulonephritis Liver Cirrhosis, Experimental carotid artery disease glioblastoma invasive ductal breast carcinoma limb-girdle muscular dystrophy lung cancer malignant ependymoma B-cell chronic lymphocytic leukemia nasopharyngeal carcinoma breast cancer pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma cutaneous lupus erythematosus Sjogren syndrome IgA glomerulonephritis Liver Cirrhosis, Experimental carotid artery disease glioblastoma invasive ductal breast carcinoma limb-girdle muscular dystrophy lung cancer malignant ependymoma B-cell chronic lymphocytic leukemia nasopharyngeal carcinoma breast cancer pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma cutaneous lupus erythematosus Sjogren syndrome Duchenne muscular dystrophy type 2 diabetes mellitus head and neck cancer juvenile dermatomyositis lung carcinoma astrocytic tumor medulloblastoma Becker muscular dystrophy ovarian cancer cancer pancreatic intraductal papillary-mucinous neoplasm chronic obstructive pulmonary disease pituitary cancer dermatomyositis ulcerative colitis hepatocellular carcinoma interstitial cystitis large cell medulloblastoma lung adenocarcinoma adrenal cortex carcinoma malignant colon neoplasm atopic eczema myopathy brain aneurysm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia congestive heart failure schizophrenia diabetes mellitus tuberculosis