9FOS | pdb_00009fos

The structure of ornithine decarboxylase from Leishmania infantum in complex with PLP and DFMO

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02784	Pyridoxal-dependent decarboxylase, pyridoxal binding domain (Orn_Arg_deC_N)	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	These pyridoxal-dependent decarboxylases acting on ornithine, lysine, arginine and related substrates This domain has a TIM barrel fold.	Domain
A	PF00278	Pyridoxal-dependent decarboxylase, C-terminal sheet domain (Orn_DAP_Arg_deC)	Pyridoxal-dependent decarboxylase, C-terminal sheet domain	These pyridoxal-dependent decarboxylases act on ornithine, lysine, arginine and related substrates.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ornithine decarboxylase	ornithine decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity	oxoacid metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process arginine metabolic process biogenic amine biosynthetic process putrescine metabolic process small molecule metabolic process putrescine biosynthetic process from arginine, via ornithine carboxylic acid metabolic process primary metabolic process polyamine metabolic process L-amino acid metabolic process oxoacid metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process arginine metabolic process biogenic amine biosynthetic process putrescine metabolic process small molecule metabolic process putrescine biosynthetic process from arginine, via ornithine carboxylic acid metabolic process primary metabolic process polyamine metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process putrescine biosynthetic process amine metabolic process biosynthetic process amine biosynthetic process polyamine biosynthetic process putrescine biosynthetic process from arginine metabolic process cellular process biogenic amine metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002433	Ornithine decarboxylase	Family
A	IPR029066	PLP-binding barrel	Homologous Superfamily
A	IPR022643	Orn/DAP/Arg decarboxylase 2, C-terminal	Domain
A	IPR009006	Alanine racemase/group IV decarboxylase, C-terminal	Homologous Superfamily
A	IPR000183	Ornithine/DAP/Arg decarboxylase	Family
A	IPR022657	Orn/DAP/Arg decarboxylase 2, conserved site	Conserved Site
A	IPR022644	Orn/DAP/Arg decarboxylase 2, N-terminal	Domain
A	IPR022653	Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site	Binding Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.