Annotations: 9GLW

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motili ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	peptide MPB2	-	-	-
A	GTPase NRas	guanyl nucleotide binding binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding guanyl nucleotide binding binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity molecular function regulator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity GTP binding purine ribonucleoside triphosphate binding	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation biological regulation positive regulation of biological process regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation cellular process regulation of epithelial cell proliferation epithelial cell proliferation regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation biological regulation positive regulation of biological process regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation cellular process regulation of epithelial cell proliferation epithelial cell proliferation positive regulation of cellular process cellular response to stimulus response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction small GTPase-mediated signal transduction Ras protein signal transduction	membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane Golgi apparatus Golgi membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol cell periphery plasma membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005225	Small GTP-binding domain	Domain
A	IPR020849	Small GTPase, Ras-type	Family
A	IPR001806	Small GTPase	Family
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P01111	juvenile myelomonocytic leukemia Noonan syndrome large congenital melanocytic nevus autoimmune lymphoproliferative syndrome thyroid cancer, nonmedullary, 2 Noonan syndrome 6 melanoma neurofibrosarcoma nevus, epidermal neurocutaneous melanocytosis cancer colorectal cancer neuroblastoma autoimmune lymphoproliferative syndrome type 4 cutaneous melanoma juvenile myelomonocytic leukemia Noonan syndrome large congenital melanocytic nevus autoimmune lymphoproliferative syndrome thyroid cancer, nonmedullary, 2 Noonan syndrome 6 melanoma neurofibrosarcoma nevus, epidermal neurocutaneous melanocytosis cancer colorectal cancer neuroblastoma autoimmune lymphoproliferative syndrome type 4 cutaneous melanoma acute myeloid leukemia acute promyelocytic leukemia Leukemia, Megakaryoblastic, of Down Syndrome rectal neoplasm lymphoma B-cell neoplasm woolly hair nevus gastric adenocarcinoma hematologic disease hydrops fetalis non-small cell lung carcinoma inflammatory linear verrucous epidermal nevus ovarian cancer chronic myelogenous leukemia, BCR-ABL1 positive medulloblastoma thyroid gland carcinoma congenital anemia giant congenital nevus Hutchinson-Gilford progeria syndrome hypertrophic cardiomyopathy atypical teratoid rhabdoid tumor intellectual disability autoimmune lymphoproliferative syndrome type 2B pancreatic ductal adenocarcinoma rectal cancer Charcot-Marie-Tooth disease lung adenocarcinoma rectum adenocarcinoma chronic myelomonocytic leukemia malignant glioma colorectal carcinoma thyroid gland papillary carcinoma verrucous nevus glioblastoma hydrocephalus IgA glomerulonephritis Noonan syndrome 1 juvenile dermatomyositis osteosarcoma leukemia plasma cell myeloma breast cancer linear nevus sebaceus syndrome rectal carcinoma cholangiocarcinoma lung cancer skin disease colorectal adenocarcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	CCS	Parent Component: CYS
B	NH2	RESID: AA0081 , AA0083 , AA0084 , AA0086 , AA0087 , AA0088 , AA0090 , AA0091 , AA0092 , AA0093 , AA0095 , AA0096 , AA0097 , AA0098 , AA0099 , AA0100 PSI-MOD : L-alanine amide MOD:00090 , L-asparagine amide MOD:00092 , L-aspartic acid 1-amide MOD:00093 , L-glutamine amide MOD:00095 , L-glutamic acid 1-amide MOD:00096 , glycine amide MOD:00097 , L-isoleucine amide MOD:00099 , L-leucine amide MOD:00100 , L-lysine amide MOD:00101 , L-methionine amide MOD:00102 , L-proline amide MOD:00104 , L-serine amide MOD:00105 , L-threonine amide MOD:00106 , L-tryptophan amide MOD:00107 , L-tyrosine amide MOD:00108 , L-valine amide MOD:00109

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.