9GMY | pdb_00009gmy

Tubulin in complex with an oxathiane analog of zampanolide

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D	Tubulin beta-2B chain	protein heterodimerization activity protein binding binding protein dimerization activity structural constituent of cytoskeleton structural molecule activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding protein heterodimerization activity protein binding binding protein dimerization activity structural constituent of cytoskeleton structural molecule activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular process cell cycle mitotic cell cycle multicellular organismal process axonogenesis regulation of cellular process response to stimulus cell projection organization neuron projection development multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis taxis cellular process cell cycle mitotic cell cycle multicellular organismal process axonogenesis regulation of cellular process response to stimulus cell projection organization neuron projection development multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis taxis regulation of axon guidance cell differentiation anatomical structure development positive regulation of cell projection organization system development developmental process chemotaxis regulation of biological process regulation of cell projection organization response to external stimulus nervous system development generation of neurons regulation of response to stimulus response to chemical regulation of locomotion regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of response to external stimulus plasma membrane bounded cell projection morphogenesis positive regulation of biological process cell development cell morphogenesis cellular component organization neurogenesis positive regulation of neuron projection development positive regulation of axon guidance cellular component organization or biogenesis locomotion positive regulation of cellular process plasma membrane bounded cell projection organization biological regulation axon guidance axon development regulation of chemotaxis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron projection guidance neuron development regulation of plasma membrane bounded cell projection organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoskeleton organization neuron migration cell migration cell motility	cellular anatomical structure intracellular anatomical structure cytoplasm polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton
A, C	Tubulin alpha-1B chain	RNA binding double-stranded RNA binding binding nucleic acid binding structural constituent of cytoskeleton structural molecule activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding RNA binding double-stranded RNA binding binding nucleic acid binding structural constituent of cytoskeleton structural molecule activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization response to interleukin-4 response to peptide response to stimulus response to chemical response to cytokine cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization response to interleukin-4 response to peptide response to stimulus response to chemical response to cytokine cellular response to cytokine stimulus cellular response to interleukin-4	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol polymeric cytoskeletal fiber intracellular membraneless organelle cytoplasmic microtubule intracellular organelle cytoskeleton membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol polymeric cytoskeletal fiber intracellular membraneless organelle cytoplasmic microtubule intracellular organelle cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton
E	Stathmin-4	cytoskeletal protein binding protein binding binding tubulin binding	regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of biological process regulation of cellular component organization regulation of cellular process microtubule cytoskeleton organization biological regulation regulation of microtubule-based process regulation of organelle organization cellular component organization organelle organization microtubule polymerization or depolymerization cellular process microtubule-based process regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of biological process regulation of cellular component organization regulation of cellular process microtubule cytoskeleton organization biological regulation regulation of microtubule-based process regulation of organelle organization cellular component organization organelle organization microtubule polymerization or depolymerization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization regulation of microtubule cytoskeleton organization cellular component disassembly protein-containing complex organization protein-containing complex disassembly microtubule depolymerization supramolecular fiber organization protein depolymerization developmental process multicellular organismal process plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development anatomical structure development system development	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system growth cone axon cell projection distal axon neuron projection membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system growth cone axon cell projection distal axon neuron projection plasma membrane bounded cell projection site of polarized growth
F	Tubulin tyrosine ligase	acid-amino acid ligase activity catalytic activity, acting on a protein tubulin-tyrosine ligase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity cation binding ion binding binding metal ion binding small molecule binding	macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process positive regulation of cell cycle mitotic cell cycle macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process positive regulation of cell cycle mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle cell cycle regulation of cell cycle positive regulation of cellular process regulation of localization metaphase chromosome alignment localization chromosome localization organelle localization nuclear chromosome segregation regulation of metaphase plate congression chromosome segregation cell cycle process cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization	polymeric cytoskeletal fiber intracellular anatomical structure spindle intracellular membraneless organelle spindle microtubule intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex polymeric cytoskeletal fiber intracellular anatomical structure spindle intracellular membraneless organelle spindle microtubule intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
B, D	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
B, D	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
B, D	IPR017975	Tubulin, conserved site	Conserved Site
B, D	IPR000217	Tubulin	Family
B, D	IPR023123	Tubulin, C-terminal	Homologous Superfamily
B, D	IPR002453	Beta tubulin	Family
B, D	IPR013838	Beta tubulin, autoregulation binding site	Binding Site
B, D	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
B, D	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily
A, C	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
A, C	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
A, C	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
A, C	IPR017975	Tubulin, conserved site	Conserved Site
A, C	IPR002452	Alpha tubulin	Family
A, C	IPR000217	Tubulin	Family
A, C	IPR023123	Tubulin, C-terminal	Homologous Superfamily
A, C	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
A, C	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily
E	IPR000956	Stathmin family	Family
E	IPR030514	Stathmin, conserved site	Conserved Site
E	IPR036002	Stathmin superfamily	Homologous Superfamily
F	IPR052492	Tubulin--tyrosine ligase	Family
F	IPR004344	Tubulin-tyrosine ligase/Tubulin polyglutamylase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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Tubulin in complex with an oxathiane analog of zampanolide

External Resource: Annotation

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage

9GMY | pdb_00009gmy