9GR8 | pdb_00009gr8

Crystal structure of the N-terminal kinase domain from Saccharomyces cerevisiae Vip1 in complex with ADP.

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08443	RimK-like ATP-grasp domain (RimK)	RimK-like ATP-grasp domain	This ATP-grasp domain is found in the ribosomal S6 modification enzyme RimK [1].	Domain
A	PF18086	Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain (PPIP5K2_N)	Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain	This is the N-terminal domain found in the Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (PPIP5K2), EC:2.7.4.24. Structure analysis of human PPIP5K2 indicate that this region forms alpha-beta-alpha domain [1].PPIP5K2 is o ...	This is the N-terminal domain found in the Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (PPIP5K2), EC:2.7.4.24. Structure analysis of human PPIP5K2 indicate that this region forms alpha-beta-alpha domain [1].PPIP5K2 is one of the mammalian PPIP5K isoforms responsible for synthesis of diphosphoinositol polyphosphates (inositol pyrophosphates; PP-InsPs), regulatory molecules that function at the interface of cell signaling and organismic homeostasis [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding inositol hexakisphosphate 5-kinase activity kinase activity transferase activity inositol hexakisphosphate kinase activity inositol phosphate kinase activity catalytic activity phosphotransferase activity, phosphate group as acceptor transferase activity, transferring phosphorus-containing groups inositol hexakisphosphate 4-kinase activity pyrophosphatase activity inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity inositol diphosphate pentakisphosphate diphosphatase activity diphosphoinositol-polyphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides inositol hexakisphosphate 1-kinase activity diphosphoinositol pentakisphosphate kinase activity 5-diphosphoinositol pentakisphosphate 1-kinase activity inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity inositol hexakisphosphate 3-kinase activity inositol hexakisphosphate 6-kinase activity	polyol metabolic process inositol metabolic process alcohol metabolic process small molecule metabolic process metabolic process cellular process small molecule biosynthetic process inositol phosphate metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process inositol phosphate biosynthetic process phosphate-containing compound metabolic process polyol biosynthetic process polyol metabolic process inositol metabolic process alcohol metabolic process small molecule metabolic process metabolic process cellular process small molecule biosynthetic process inositol phosphate metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process inositol phosphate biosynthetic process phosphate-containing compound metabolic process polyol biosynthetic process alcohol biosynthetic process phosphorus metabolic process regulation of growth regulation of cellular component organization regulation of cellular process regulation of developmental process developmental growth unidimensional cell growth cell morphogenesis cell growth regulation of cell morphogenesis cellular component organization anatomical structure development cellular component organization or biogenesis regulation of bipolar cell growth regulation of anatomical structure morphogenesis developmental process bipolar cell growth regulation of biological process regulation of developmental growth growth biological regulation regulation of cell growth developmental growth involved in morphogenesis regulation of unidimensional cell growth anatomical structure morphogenesis regulation of cytoskeleton organization microtubule cytoskeleton organization regulation of microtubule-based process regulation of organelle organization organelle organization microtubule-based process regulation of microtubule cytoskeleton organization cytoskeleton organization	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000560	Histidine phosphatase superfamily, clade-2	Family
A	IPR029033	Histidine phosphatase superfamily	Homologous Superfamily
A	IPR037446	Histidine acid phosphatase, VIP1 family	Family
A	IPR013651	ATP-grasp fold, RimK-type	Domain
A	IPR040557	VIP1, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.