9KBE | pdb_00009kbe

Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with indolcarboxamide

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Trehalose monomycolate exporter MmpL3	binding phospholipid binding lipid binding phosphatidylinositol binding phosphatidylethanolamine binding phospholipid transfer activity lipid transporter activity lipid transfer activity transporter activity phospholipid transporter activity phosphatidylethanolamine transfer activity diacylglycerol binding ion binding anion binding binding phospholipid binding lipid binding phosphatidylinositol binding phosphatidylethanolamine binding phospholipid transfer activity lipid transporter activity lipid transfer activity transporter activity phospholipid transporter activity phosphatidylethanolamine transfer activity diacylglycerol binding ion binding anion binding phosphatidylglycerol binding cardiolipin binding small molecule binding trehalose transmembrane transporter activity disaccharide transmembrane transporter activity oligosaccharide transmembrane transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity	response to stimulus response to chemical response to xenobiotic stimulus oxoacid metabolic process cell wall organization or biogenesis lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process cellular component biogenesis mycolic acid biosynthetic process Actinobacterium-type cell wall biogenesis small molecule metabolic process cellular component organization or biogenesis response to stimulus response to chemical response to xenobiotic stimulus oxoacid metabolic process cell wall organization or biogenesis lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process cellular component biogenesis mycolic acid biosynthetic process Actinobacterium-type cell wall biogenesis small molecule metabolic process cellular component organization or biogenesis peptidoglycan-based cell wall biogenesis fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process macromolecule biosynthetic process cell wall biogenesis biosynthetic process cell wall macromolecule biosynthetic process cellular process metabolic process macromolecule metabolic process monocarboxylic acid metabolic process cell wall macromolecule metabolic process lipid metabolic process biological regulation regulation of biological quality regulation of membrane potential cellular component organization cell wall organization external encapsulating structure organization response to antibiotic localization transport macromolecule localization phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport trehalose transport carbohydrate transport oligosaccharide transport disaccharide transport mycolate cell wall layer assembly cellular component assembly	cellular anatomical structure cell tip cell pole cell septum cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004869	Membrane transport protein MMPL domain	Domain
A	IPR050545	Mycobacterial membrane protein Large (MmpL)	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.