9M3O | pdb_00009m3o

Crystal structure of human pyruvate dehydrogenase kinase isoform 1 in complex with ATP competitive inhibitor 8

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02518	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	Domain
A	PF10436	Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase (BCDHK_Adom3)	Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups	cell population proliferation cellular process response to decreased oxygen levels cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cellular response to oxygen levels signaling cellular response to hypoxia biological regulation cellular response to decreased oxygen levels intracellular signal transduction cell communication cell population proliferation cellular process response to decreased oxygen levels cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cellular response to oxygen levels signaling cellular response to hypoxia biological regulation cellular response to decreased oxygen levels intracellular signal transduction cell communication cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical hypoxia-inducible factor-1alpha signaling pathway response to oxygen levels response to abiotic stimulus signal transduction aerobic respiration regulation of acyl-CoA biosynthetic process regulation of amide metabolic process oxoacid metabolic process regulation of lipid metabolic process acetyl-CoA metabolic process organic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of sulfur metabolic process regulation of small molecule metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process sulfur compound metabolic process small molecule metabolic process thioester metabolic process regulation of nucleobase-containing compound metabolic process phosphorus metabolic process nucleoside phosphate metabolic process pyruvate metabolic process pyruvate decarboxylation to acetyl-CoA primary metabolic process amide biosynthetic process regulation of ketone metabolic process sulfur compound biosynthetic process biosynthetic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process regulation of fatty acid metabolic process metabolic process regulation of phosphorus metabolic process monocarboxylic acid metabolic process regulation of metabolic process cellular respiration energy derivation by oxidation of organic compounds thioester biosynthetic process ketone metabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process acyl-CoA biosynthetic process regulation of pyruvate decarboxylation to acetyl-CoA amide metabolic process regulation of biosynthetic process fatty acid metabolic process carboxylic acid metabolic process generation of precursor metabolites and energy nucleobase-containing compound biosynthetic process purine-containing compound metabolic process acetyl-CoA biosynthetic process organophosphate metabolic process lipid metabolic process intrinsic apoptotic signaling pathway in response to oxidative stress cell death apoptotic signaling pathway apoptotic process intrinsic apoptotic signaling pathway programmed cell death monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process glucose metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex transferase complex pyruvate dehydrogenase complex acetyltransferase complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex transferase complex pyruvate dehydrogenase complex acetyltransferase complex alpha-ketoacid dehydrogenase complex membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR039028	PDK/BCKDK protein kinase	Family
A	IPR036784	Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily	Homologous Superfamily
A	IPR018955	Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal	Domain
A	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A	IPR005467	Histidine kinase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q15118	psoriasis astrocytic tumor breast cancer interstitial cystitis lung cancer Mitochondrial Diseases ovarian cancer Pick disease sinusitis attention deficit hyperactivity disorder, inattentive type cystic fibrosis large cell medulloblastoma malignant ependymoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma psoriasis astrocytic tumor breast cancer interstitial cystitis lung cancer Mitochondrial Diseases ovarian cancer Pick disease sinusitis attention deficit hyperactivity disorder, inattentive type cystic fibrosis large cell medulloblastoma malignant ependymoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma progressive supranuclear palsy atypical teratoid rhabdoid tumor glioblastoma lung adenocarcinoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.