9OVJ | pdb_00009ovj

Structure of human SHOC2 in complex with a small molecule inhibitor (R)-5

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Leucine-rich repeat protein SHOC-2	enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity volume-sensitive anion channel activity monoatomic anion transmembrane transporter activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity protein phosphatase binding enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity volume-sensitive anion channel activity monoatomic anion transmembrane transporter activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding protein phosphatase 1 binding	multicellular organismal process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation negative regulation of cellular process anatomical structure development negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation negative regulation of cellular process anatomical structure development negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation cellular response to stimulus cellular response to growth factor stimulus response to stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus cellular response to nerve growth factor stimulus cell communication cellular response to endogenous stimulus nerve growth factor signaling pathway neurotrophin signaling pathway response to nerve growth factor response to growth factor signal transduction regulation of signaling regulation of signal transduction regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette MAPK cascade regulation of cell communication regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization positive regulation of neuron projection development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process plasma membrane bounded cell projection organization regulation of cell projection organization neuron development regulation of plasma membrane bounded cell projection organization positive regulation of neuron differentiation positive regulation of developmental process positive regulation of cell differentiation response to fibroblast growth factor cell surface receptor protein tyrosine kinase signaling pathway fibroblast growth factor receptor signaling pathway cellular response to fibroblast growth factor stimulus enzyme-linked receptor protein signaling pathway import into cell nitrogen compound transport guanine nucleotide transmembrane transport organic anion transport nucleotide transport transport purine ribonucleotide transport import across plasma membrane carbohydrate derivative transport establishment of localization purine nucleotide transport transmembrane transport adenine nucleotide transport localization nucleotide transmembrane transport cyclic-GMP-AMP transmembrane import across plasma membrane guanine nucleotide transport cyclic nucleotide transport nucleobase-containing compound transport organophosphate ester transport purine-containing compound transmembrane transport negative regulation of cell population proliferation negative regulation of neural precursor cell proliferation cell population proliferation regulation of cell population proliferation neural precursor cell proliferation regulation of neural precursor cell proliferation cellular response to nitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to growth hormone stimulus cellular response to oxygen-containing compound response to growth hormone cellular response to chemical stimulus response to hormone response to chemical cellular response to hormone stimulus positive regulation of cell communication small GTPase-mediated signal transduction positive regulation of signal transduction regulation of small GTPase mediated signal transduction positive regulation of response to stimulus regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction Ras protein signal transduction positive regulation of intracellular signal transduction positive regulation of small GTPase mediated signal transduction positive regulation of signaling	phosphatase complex protein-containing complex protein phosphatase type 1 complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm protein serine/threonine phosphatase complex cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen phosphatase complex protein-containing complex protein phosphatase type 1 complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm protein serine/threonine phosphatase complex cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A	IPR001611	Leucine-rich repeat	Repeat
A	IPR050216	Leucine-rich repeat domain-containing protein	Family
A	IPR055414	Disease resistance R13L4/SHOC-2-like, LRR domain	Domain
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UQ13	Noonan syndrome Noonan syndrome-like disorder with loose anagen hair 1 disease of pilosebaceous unit cardiofaciocutaneous syndrome Female Pseudo-Turner Syndrome intellectual disability malignant glioma Noonan syndrome-like disorder with loose anagen hair plasma cell myeloma Costello syndrome hydrops fetalis large cell medulloblastoma hypertrophic cardiomyopathy lymphoplasmacytic lymphoma Noonan syndrome with multiple lentigines Noonan syndrome Noonan syndrome-like disorder with loose anagen hair 1 disease of pilosebaceous unit cardiofaciocutaneous syndrome Female Pseudo-Turner Syndrome intellectual disability malignant glioma Noonan syndrome-like disorder with loose anagen hair plasma cell myeloma Costello syndrome hydrops fetalis large cell medulloblastoma hypertrophic cardiomyopathy lymphoplasmacytic lymphoma Noonan syndrome with multiple lentigines ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.