9PQ6 | pdb_00009pq6

MBP-Mcl1 in complex with ligand 12

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1	transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity protein heterodimerization activity protein binding protein dimerization activity transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity protein heterodimerization activity protein binding protein dimerization activity death domain binding BH3 domain binding BH domain binding protein domain specific binding passive transmembrane transporter activity channel activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cell motility cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cell motility locomotion localization transport carbohydrate transport oligosaccharide transport disaccharide transport establishment of localization maltose transport polysaccharide localization dextrin transport macromolecule localization maltodextrin transmembrane transport polysaccharide transport response to disaccharide response to oxygen-containing compound detection of maltose stimulus detection of stimulus response to carbohydrate detection of chemical stimulus detection of disaccharide stimulus response to maltose detection of carbohydrate stimulus positive regulation of cell communication intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process regulation of cellular process positive regulation of signal transduction regulation of oxidative stress-induced intrinsic apoptotic signaling pathway signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction signal transduction intrinsic apoptotic signaling pathway positive regulation of neuron apoptotic process positive regulation of cellular process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of biological process regulation of signaling positive regulation of programmed cell death regulation of apoptotic process biological regulation positive regulation of intracellular signal transduction cell death positive regulation of apoptotic process neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway regulation of response to stimulus positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway apoptotic process programmed cell death regulation of neuron apoptotic process regulation of apoptotic signaling pathway positive regulation of signaling cellular homeostasis homeostatic process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand signal transduction in absence of ligand negative regulation of signaling negative regulation of biological process negative regulation of cell communication extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process extrinsic apoptotic signaling pathway in absence of ligand cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway in absence of ligand organelle fusion cellular component organization organelle organization mitochondrial fusion cellular component organization or biogenesis mitochondrion organization regulation of anoikis negative regulation of anoikis anoikis response to peptide response to cytokine developmental process cellular developmental process cell differentiation cell fate determination cell fate commitment intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of catabolic process catabolic process negative regulation of metabolic process autophagy regulation of catabolic process regulation of autophagy negative regulation of autophagy metabolic process process utilizing autophagic mechanism regulation of metabolic process apoptotic mitochondrial changes release of cytochrome c from mitochondria	ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex transporter complex ATP-binding cassette (ABC) transporter complex cell periphery cellular anatomical structure transmembrane transporter complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing maltose transport complex periplasmic space ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex transporter complex ATP-binding cassette (ABC) transporter complex cell periphery cellular anatomical structure transmembrane transporter complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing maltose transport complex periplasmic space outer membrane-bounded periplasmic space cell envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol Bcl-2 family protein complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen mitochondrial membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR006061	Solute-binding family 1, conserved site	Conserved Site
A	IPR006060	Maltose/Cyclodextrin ABC transporter, substrate-binding protein	Family
A	IPR006059	Bacterial-type extracellular solute-binding protein	Family
A	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site	Conserved Site
A	IPR036834	Bcl-2-like superfamily	Homologous Superfamily
A	IPR046371	Bcl-2, Bcl-2 homology region 1-3	Domain
A	IPR002475	Bcl2-like	Family
A	IPR026298	Bcl-2 family	Family
A	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	Conserved Site
A	IPR013281	Apoptosis regulator, Mcl-1	Family
A	IPR020728	Apoptosis regulator, Bcl-2, BH3 motif, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q07820	Barrett esophagus plasma cell myeloma leishmaniasis spindle cell sarcoma primary cutaneous T-cell non-Hodgkin lymphoma sarcoma interstitial lung disease subependymal giant cell astrocytoma lung carcinoma Lymphoma, T-Cell, Cutaneous adenoma myeloid neoplasm cancer osteosarcoma diabetes mellitus Barrett esophagus plasma cell myeloma leishmaniasis spindle cell sarcoma primary cutaneous T-cell non-Hodgkin lymphoma sarcoma interstitial lung disease subependymal giant cell astrocytoma lung carcinoma Lymphoma, T-Cell, Cutaneous adenoma myeloid neoplasm cancer osteosarcoma diabetes mellitus Pick disease gastric cancer plasma cell neoplasm glioblastoma primitive neuroectodermal tumor hereditary spastic paraplegia sinusitis ulcerative colitis invasive ductal breast carcinoma lung benign neoplasm malignant ependymoma astrocytic tumor malignant pancreatic neoplasm non-small cell lung carcinoma chronic obstructive pulmonary disease ovarian cancer Down syndrome pilocytic astrocytoma gastric carcinoma polycystic ovary syndrome granulomatous slack skin disease psoriasis interstitial cystitis large cell medulloblastoma lung cancer lymphatic system disease malignant glioma atypical teratoid rhabdoid tumor medulloblastoma breast carcinoma osteoarthritis cutaneous lupus erythematosus pancreatic ductal adenocarcinoma epithelioid sarcoma Gaucher disease hematologic disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.