9R0U | pdb_00009r0u

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00194	Eukaryotic-type carbonic anhydrase (Carb_anhydrase)	Eukaryotic-type carbonic anhydrase		Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Carbonic anhydrase 12	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding carbonate dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity	inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis chloride ion homeostasis monoatomic anion homeostasis ovulation cycle rhythmic process estrous cycle reproductive process multicellular organismal reproductive process	cell periphery cellular anatomical structure plasma membrane membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane apical part of cell apical plasma membrane

Chains	Accession	Name	Type
A, B, C, D	IPR018338	Carbonic anhydrase, alpha-class, conserved site	Conserved Site
A, B, C, D	IPR001148	Alpha carbonic anhydrase domain	Domain
A, B, C, D	IPR036398	Alpha carbonic anhydrase domain superfamily	Homologous Superfamily
A, B, C, D	IPR023561	Carbonic anhydrase, alpha-class	Family

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: O43570	isolated hyperchlorhidrosis Lung Neoplasms nephrosclerosis adrenal cortex carcinoma open-angle glaucoma atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma breast fibroadenoma cystic fibrosis sinusitis glioblastoma lung cancer malignant colon neoplasm malignant glioma malignant pancreatic neoplasm isolated hyperchlorhidrosis Lung Neoplasms nephrosclerosis adrenal cortex carcinoma open-angle glaucoma atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma breast fibroadenoma cystic fibrosis sinusitis glioblastoma lung cancer malignant colon neoplasm malignant glioma malignant pancreatic neoplasm non-small cell lung carcinoma angle-closure glaucoma osteosarcoma breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia childhood absence epilepsy psoriasis dental caries subependymal giant cell astrocytoma heart disease large cell medulloblastoma lung carcinoma malignant ependymoma malignant mesothelioma medulloblastoma oligodendroglioma ovarian cancer breast carcinoma cutaneous lupus erythematosus ulcerative colitis interstitial cystitis lung benign neoplasm