9VIZ | pdb_00009viz

Cryo-EM structure of palytoxin-bound Na+,K+-ATPase in the transient state of dephosphorylation (E2~P)

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth G], F [auth E]	PF02038	ATP1G1/PLM/MAT8 family (ATP1G1_PLM_MAT8)	ATP1G1/PLM/MAT8 family	-	Family
A, D [auth C]	PF00689	Cation transporting ATPase, C-terminus (Cation_ATPase_C)	Cation transporting ATPase, C-terminus	-	Family
A, D [auth C]	PF00702	haloacid dehalogenase-like hydrolase (Hydrolase)	haloacid dehalogenase-like hydrolase	This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted fo ...	This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain [1]. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria [2].	Domain
A, D [auth C]	PF00690	Cation transporter/ATPase, N-terminus (Cation_ATPase_N)	Cation transporter/ATPase, N-terminus	Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.	Domain
A, D [auth C]	PF00122	E1-E2 ATPase (E1-E2_ATPase)	E1-E2 ATPase	-	Family
A, D [auth C]	PF13246	Cation transport ATPase (P-type) (Cation_ATPase)	Cation transport ATPase (P-type)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C [auth G], F [auth E]	FXYD domain-containing ion transport regulator	channel regulator activity ion channel regulator activity molecular function regulator activity sodium channel regulator activity transporter regulator activity	regulation of localization localization regulation of biological process regulation of transport transport regulation of monoatomic ion transport biological regulation monoatomic ion transport establishment of localization	cellular anatomical structure membrane
B, E [auth D]	Na+,K+-ATPase beta subunit	ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity	potassium ion homeostasis inorganic ion homeostasis homeostatic process cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis intracellular potassium ion homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis sodium ion homeostasis intracellular sodium ion homeostasis transport potassium ion homeostasis inorganic ion homeostasis homeostatic process cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis intracellular potassium ion homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis sodium ion homeostasis intracellular sodium ion homeostasis transport sodium ion export across plasma membrane monoatomic ion transmembrane transport sodium ion transmembrane transport export from cell inorganic ion transmembrane transport export across plasma membrane establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport sodium ion transport import into cell import across plasma membrane potassium ion transmembrane transport inorganic cation import across plasma membrane inorganic ion import across plasma membrane potassium ion transport potassium ion import across plasma membrane	ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex sodium:potassium-exchanging ATPase complex transporter complex cation-transporting ATPase complex cell periphery cellular anatomical structure transmembrane transporter complex
A, D [auth C]	Na, K-ATPase alpha subunit	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity P-type sodium transporter activity potassium ion transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity P-type sodium:potassium-exchanging transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity sodium ion transmembrane transporter activity P-type potassium transmembrane transporter activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cation binding metal ion binding	potassium ion homeostasis inorganic ion homeostasis homeostatic process cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis intracellular potassium ion homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis sodium ion homeostasis intracellular sodium ion homeostasis transport potassium ion homeostasis inorganic ion homeostasis homeostatic process cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis intracellular potassium ion homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis sodium ion homeostasis intracellular sodium ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport sodium ion export across plasma membrane sodium ion transmembrane transport export from cell export across plasma membrane metal ion transport sodium ion transport import into cell import across plasma membrane potassium ion transmembrane transport inorganic cation import across plasma membrane inorganic ion import across plasma membrane potassium ion transport potassium ion import across plasma membrane	cellular anatomical structure membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth G], F [auth E]	IPR047297	Ion-transport regulator, FXYD motif	Conserved Site
C [auth G], F [auth E]	IPR000272	Ion-transport regulator, FXYD family	Family
B, E [auth D]	IPR000402	Sodium/potassium-transporting ATPase subunit beta	Family
B, E [auth D]	IPR038702	Sodium/potassium-transporting ATPase subunit beta superfamily	Homologous Superfamily
A, D [auth C]	IPR005775	P-type ATPase subfamily IIC, subunit alpha	Family
A, D [auth C]	IPR004014	Cation-transporting P-type ATPase, N-terminal	Domain
A, D [auth C]	IPR023214	HAD superfamily	Homologous Superfamily
A, D [auth C]	IPR008250	P-type ATPase, A domain superfamily	Homologous Superfamily
A, D [auth C]	IPR001757	P-type ATPase	Family
A, D [auth C]	IPR044492	P-type ATPase, haloacid dehalogenase domain	Domain
A, D [auth C]	IPR006068	Cation-transporting P-type ATPase, C-terminal	Domain
A, D [auth C]	IPR018303	P-type ATPase, phosphorylation site	PTM
A, D [auth C]	IPR036412	HAD-like superfamily	Homologous Superfamily
A, D [auth C]	IPR023298	P-type ATPase, transmembrane domain superfamily	Homologous Superfamily
A, D [auth C]	IPR023299	P-type ATPase, cytoplasmic domain N	Homologous Superfamily
A, D [auth C]	IPR050510	Cation transport ATPase (P-type)	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.