Trivalent organoarsenical cleaving enzyme

UniProtKB accession:  D1A230

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Nonheme iron-dependent dioxygenase that can break carbon-arsenic bonds, playing a role in the detoxification of environmental organoarsenical compounds. Catalyzes the oxygen-dependent demethylation of highly toxic methylarsonous acid (MAs(III)) to arsenite, which can then be exported out of the cell (PubMed:27107642, PubMed:35487149). Can also cleave the C-As bond in several trivalent aromatic arsenicals, including roxarsone (III), nitarsone (III) and (4-aminophenyl)arsonous acid (By similarity). Organoarsenical degradation by this enzyme is proposed to have a significant impact on the arsenic biogeocycle that maintains a balance between organic and inorganic species (Probable).