Translocation and assembly module subunit TamA

UniProtKB accession:  P0ADE4

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Component of the translocation and assembly module (TAM), which facilitates the insertion and assembly of specific beta-barrel proteins into the outer membrane (PubMed:22466966, PubMed:25341963, PubMed:28752534, PubMed:39174534). Promotes the assembly and secretion across the outer membrane of a subset of autotransporters, such as Ag43 (PubMed:22466966, PubMed:25341963). Involved in the assembly of the outer membrane usher protein FimD (PubMed:28752534). In vitro, when TAM is reconstituted into preformed liposomes, it can promote the assembly of several outer membrane proteins, including OmpA, EspP, Ag43 and FadL (PubMed:39174534). TamA is sufficient to catalyze a low level of outer membrane protein (OMP) assembly, but both TamA and TamB are required for efficient OMP assembly (PubMed:39174534). TamA must bind to the beta signal of client proteins to promote their assembly (PubMed:39174534). Has anion selective channel-forming ability, but the physiological relevance of this activity is unclear (PubMed:17214547).