L-glyceraldehyde 3-phosphate reductase

UniProtKB accession:  Q46851

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UniProtKB description:  Aldo-keto reductase that catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP) to L-glycerol 3-phosphate (L-G3P) (PubMed:18620424). The physiological role of Gpr is the detoxification of L-GAP, which may be formed via non-enzymatic and/or enzymatic racemization of D-GAP (PubMed:18620424). Also contributes to cellular methylglyoxal detoxification by catalyzing the NADPH-dependent conversion of methylglyoxal to acetol (PubMed:12583903, PubMed:16077126). However, the catalytic efficiency of methylglyoxal reductase activity is more than 2 orders of magnitude lower than the L-GAP reductase activity (PubMed:18620424). In addition, exhibits activity with glyoxal and probably plays a significant role in detoxification of glyoxal in vivo (PubMed:23990306). Shows broad specificity and can use aromatic aldehydes such as 4-nitrobenzaldehyde and benzaldehyde, D,L-glyceraldehyde, phenylglyoxal, isatin and the model substrate 4-nitrobenzaldehyde (PubMed:12583903, PubMed:16077126).