UDP-glucose:p-hydroxymandelonitrile O-glucosyltransferase
UniProtKB accession: Q9SBL1
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Go to UniProtKB: Q9SBL1
UniProtKB description: Glucosyltransferase involved in the last step of the biosynthesis of the cyanogenic glucoside dhurrin. Catalyzes the glucosylation of p-hydroxymandelonitrile, producing dhurrin (PubMed:10585420, PubMed:12946413, PubMed:4416442). The enzyme is stereospecific for the (S) enantiomer of p-hydroxymandelonitrile (PubMed:4416442). Prevents the dissociation of p-hydroxymandelonitrile and consequent release of toxic hydrogen cyanide. In vitro, is also able to use mandelonitrile, and to a lesser extent, benzyl alcohol and geraniol, as acceptor substrates, but not hydroquinone(1,4-benzenediol), alpha-terpinol, linalool or farnesol (PubMed:10585420). UDP-glucose, and, to a lesser extent UDP-galactose, but not UDP-xylose or UDP-glucuronic acid can be used as sugar donor (PubMed:16169969).
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