Dimethylallyltryptophan synthase 1

UniProtKB accession:  S0EH60

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UniProtKB description:  Dimethylallyltryptophan synthase; part of the DMATS1 gene cluster that mediates the biosynthesis of a reversely N-prenylated monomeric L-tryptophan (r-N-DMAT) (PubMed:28295904, PubMed:36084241). DMATS1 catalyzes the reverse N-prenylation of L-Trp with DMAPP to yield N-dimethylallyl-L-tryptophan (PubMed:28295904, PubMed:36084241). DMATS1 exhibits unusually broad substrate specificity and can utilize geranyl diphosphate (GPP) or L-Tyr as an alternative prenyl donor or acceptor, respectively (PubMed:36084241). Is able to catalyze both forward and reverse prenylation, i.e., at C1 or C3 of DMAPP; and it can catalyze C-N and C-O bond-forming reactions (PubMed:36084241). The main product of the cluster is the reverse-N-dimethylallyl-L-tryptophan (r-N-DMAT) produced by the dimethylallyltryptophan synthase DMATS1 and it remains unclear whether this metabolite undergoes further modifications when silent gene clusters are activated (PubMed:28295904). The acetylated form of r-N-DMAT, ac-r-N-DMAT, is also produced (PubMed:28295904). The roles of the cytochrome P450 monooxygenase FFUJ_09176 and the methyltransferase FFUJ_09178 have still to be elucidated (Probable).