Download MendeleyCrystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation D132E
Liu, C.To be published.
9KVO | pdb_00009kvo
Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation D132E
- PDB DOI: https://doi.org/10.2210/pdb9KVO/pdb
- Classification: METAL BINDING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2024-12-05 Released: 2025-12-10
- Funding Organization(s): Not funded
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 3.14 Å
- R-Value Free: 0.345 (Depositor), 0.356 (DCC)
- R-Value Work: 0.282 (Depositor), 0.290 (DCC)
- R-Value Observed: 0.288 (Depositor)
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| KCNQ1 helixAB | 66 | Homo sapiens | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Calmodulin-1 | 149 | Homo sapiens | Mutation(s): 1 Gene Names: CALM1, CALM, CAM, CAM1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P0DP23 (Homo sapiens) Explore P0DP23 Go to UniProtKB: P0DP23 | |||||
PHAROS: P0DP23 GTEx: ENSG00000198668 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P0DP23 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| CA Query on CA | E [auth C], F [auth C], G [auth D], H [auth D] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 3.14 Å
- R-Value Free: 0.345 (Depositor), 0.356 (DCC)
- R-Value Work: 0.282 (Depositor), 0.290 (DCC)
- R-Value Observed: 0.288 (Depositor)
Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 39.888 | α = 90 |
| b = 83.365 | β = 90 |
| c = 124.234 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| HKL-3000 | data reduction |
| HKL-3000 | data scaling |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-12-10 Deposition Author(s): Liu, C.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Not funded | -- |
Revision History (Full details and data files)
- Version 1.0: 2025-12-10
Type: Initial release
