5LUG | pdb_00005lug

Crystal structure of human Spindlin-2B protein in complex with ART(M3L)QTA(2MR)KS peptide

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Spin-Ssty_1	e5lugA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_1	ECOD (1.6)
A	Spin-Ssty_2	e5lugA2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_2	ECOD (1.6)
A	Spin-Ssty	e5lugA3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty	ECOD (1.6)
B	Spin-Ssty_1	e5lugB3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_1	ECOD (1.6)
B	Spin-Ssty_2	e5lugB1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_2	ECOD (1.6)
B	Spin-Ssty	e5lugB2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty	ECOD (1.6)
C	Spin-Ssty_1	e5lugC1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_1	ECOD (1.6)
C	Spin-Ssty_2	e5lugC3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_2	ECOD (1.6)
C	Spin-Ssty	e5lugC2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty	ECOD (1.6)
D	Spin-Ssty_1	e5lugD1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_1	ECOD (1.6)
D	Spin-Ssty_2	e5lugD3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty_2	ECOD (1.6)
D	Spin-Ssty	e5lugD2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Spin-Ssty	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02513	Spin/Ssty Family (Spin-Ssty)	Spin/Ssty Family	Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo [1]. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this f ...	Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo [1]. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Spindlin-like protein 2, isoform CRA_a	methylated histone binding protein binding binding modification-dependent protein binding histone binding methylation-dependent protein binding	cellular process apoptotic process cell death programmed cell death regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process cellular process apoptotic process cell death programmed cell death regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process sexual reproduction reproductive process multicellular organismal reproductive process gamete generation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
E [auth F], F [auth G], G [auth H], H [auth E]	ALA-ARG-THR-M3L-GLN-THR-ALA-2MR-LYS-SER	DNA binding binding nucleic acid binding cell adhesion molecule binding cadherin binding protein binding protein heterodimerization activity protein dimerization activity structural molecule activity structural constituent of chromatin	protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization biosynthetic process protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process organelle organization telomere organization chromosome organization regulation of biosynthetic process regulation of biological process regulation of cellular process epigenetic regulation of gene expression biological regulation regulation of macromolecule metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of metabolic process	cellular anatomical structure membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex cellular anatomical structure membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle membraneless organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR042567	Spindlin/spermiogenesis-specific domain superfamily	Homologous Superfamily
A, B, C, D	IPR003671	Spindlin/spermiogenesis-specific protein	Family
E [auth F], F [auth G], G [auth H], H [auth E]	IPR009072	Histone-fold	Homologous Superfamily
E [auth F], F [auth G], G [auth H], H [auth E]	IPR007125	Histone H2A/H2B/H3	Domain
E [auth F], F [auth G], G [auth H], H [auth E]	IPR000164	Histone H3/CENP-A	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth F], F [auth G], G [auth H], H [auth E]	Pharos: P68431	lung carcinoma glioblastoma glioma large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma allergic rhinitis ovarian cancer autism spectrum disorder psoriasis cutaneous lupus erythematosus tuberculosis ependymoma gastric carcinoma Glioma of Brain, Familial lung carcinoma glioblastoma glioma large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma allergic rhinitis ovarian cancer autism spectrum disorder psoriasis cutaneous lupus erythematosus tuberculosis ependymoma gastric carcinoma Glioma of Brain, Familial hypertensive disorder lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm osteoarthritis astrocytoma (excluding glioblastoma) pancreatic intraductal papillary-mucinous carcinoma breast cancer spina bifida cystic fibrosis exocrine pancreatic carcinoma glioma susceptibility 1 invasive ductal breast carcinoma lung cancer malignant glioma medulloblastoma osteosarcoma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm breast carcinoma subependymoma ductal breast carcinoma in situ gastric cancer hepatocellular carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
E [auth F], F [auth G], G [auth H], H [auth E]	2MR	Parent Component: ARG RESID: AA0067 PSI-MOD : symmetric dimethyl-L-arginine MOD:00076
E [auth F], F [auth G], G [auth H], H [auth E]	M3L	Parent Component: LYS RESID: AA0067 , AA0074 PSI-MOD : symmetric dimethyl-L-arginine MOD:00076 , N6,N6,N6-trimethyl-L-lysine MOD:00083

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.