9D6Z | pdb_00009d6z

Crystal structure of Human Prostaglandin reductase 1 (PTGR1) in complex with methotrexate (Orthorhombic C form)

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Prostaglandin reductase 1	leukotriene B4 12-hydroxy dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors catalytic activity 2-alkenal reductase (NADPH) activity 2-alkenal reductase [NAD(P)H] activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-CH group of donors 15-oxoprostaglandin 13-reductase [NAD(P)+] activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13-lipoxin reductase activity	fatty acid metabolic process long-chain fatty acid metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process lipoxin metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process fatty acid derivative metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipoxin A4 metabolic process fatty acid metabolic process long-chain fatty acid metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process lipoxin metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process fatty acid derivative metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipoxin A4 metabolic process lipid metabolic process prostaglandin metabolic process icosanoid metabolic process prostanoid metabolic process leukotriene metabolic process leukotriene B4 metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR045010	Medium-chain dehydrogenase/reductase	Family
A, B	IPR014190	Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase	Family
A, B	IPR011032	GroES-like superfamily	Homologous Superfamily
A, B	IPR041694	Oxidoreductase, N-terminal domain	Domain
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR013149	Alcohol dehydrogenase-like, C-terminal	Domain
A, B	IPR020843	Enoylreductase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q14914	adenoma interstitial cystitis nasopharyngeal carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive supranuclear palsy ulcerative colitis astrocytic tumor invasive ductal breast carcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma Pick disease psoriasis heart disease malignant ependymoma adenoma interstitial cystitis nasopharyngeal carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive supranuclear palsy ulcerative colitis astrocytic tumor invasive ductal breast carcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma Pick disease psoriasis heart disease malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor transitional cell carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.