9DZO | pdb_00009dzo

Structure of ALAS bound to succinyl-CoA from S. cerevisiae

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth B]	SCOP2B Superfamily	PLP-dependent transferases	8098330	3000954	SCOP2B (2022-06-29)
D [auth E]	SCOP2B Superfamily	PLP-dependent transferases	8098330	3000954	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	PLP-dependent transferases	8098330	3000954	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	PLP-dependent transferases	8098330	3000954	SCOP2B (2022-06-29)
A [auth C]	SCOP2B Superfamily	PLP-dependent transferases	8098330	3000954	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PLP-dependent transferases	8098330	3000954	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth D], C [auth A], D [auth E], E [auth B]	PF00155	Aminotransferase class I and II (Aminotran_1_2)	Aminotransferase class I and II		Domain
F	PF00155	Aminotransferase class I and II (Aminotran_1_2)	Aminotransferase class I and II		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D], C [auth A], D [auth E], E [auth B]	5-aminolevulinate synthase, mitochondrial	vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding anion binding heterocyclic compound binding small molecule binding N-succinyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity succinyltransferase activity catalytic activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding anion binding heterocyclic compound binding small molecule binding N-succinyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity succinyltransferase activity catalytic activity 5-aminolevulinate synthase activity N-acyltransferase activity	heme metabolic process pigment metabolic process porphyrin-containing compound biosynthetic process tetrapyrrole metabolic process heme biosynthetic process pigment biosynthetic process tetrapyrrole biosynthetic process biosynthetic process metabolic process cellular process porphyrin-containing compound metabolic process protoporphyrinogen IX metabolic process protoporphyrinogen IX biosynthetic process positive regulation of organelle organization heme metabolic process pigment metabolic process porphyrin-containing compound biosynthetic process tetrapyrrole metabolic process heme biosynthetic process pigment biosynthetic process tetrapyrrole biosynthetic process biosynthetic process metabolic process cellular process porphyrin-containing compound metabolic process protoporphyrinogen IX metabolic process protoporphyrinogen IX biosynthetic process positive regulation of organelle organization regulation of biological process regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization organelle assembly positive regulation of cellular component biogenesis biological regulation positive regulation of biological process regulation of cellular component biogenesis regulation of organelle organization cellular component biogenesis cellular component organization organelle organization cellular component assembly regulation of organelle assembly cellular component organization or biogenesis positive regulation of cellular process positive regulation of organelle assembly	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen
F	5-aminolevulinate synthase, mitochondrial	vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding anion binding heterocyclic compound binding small molecule binding N-succinyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity succinyltransferase activity catalytic activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding anion binding heterocyclic compound binding small molecule binding N-succinyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity succinyltransferase activity catalytic activity 5-aminolevulinate synthase activity N-acyltransferase activity	heme metabolic process pigment metabolic process porphyrin-containing compound biosynthetic process tetrapyrrole metabolic process heme biosynthetic process pigment biosynthetic process tetrapyrrole biosynthetic process biosynthetic process metabolic process cellular process porphyrin-containing compound metabolic process protoporphyrinogen IX metabolic process protoporphyrinogen IX biosynthetic process positive regulation of organelle organization heme metabolic process pigment metabolic process porphyrin-containing compound biosynthetic process tetrapyrrole metabolic process heme biosynthetic process pigment biosynthetic process tetrapyrrole biosynthetic process biosynthetic process metabolic process cellular process porphyrin-containing compound metabolic process protoporphyrinogen IX metabolic process protoporphyrinogen IX biosynthetic process positive regulation of organelle organization regulation of biological process regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization organelle assembly positive regulation of cellular component biogenesis biological regulation positive regulation of biological process regulation of cellular component biogenesis regulation of organelle organization cellular component biogenesis cellular component organization organelle organization cellular component assembly regulation of organelle assembly cellular component organization or biogenesis positive regulation of cellular process positive regulation of organelle assembly	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth D], C [auth A], D [auth E], E [auth B]	IPR001917	Aminotransferase, class-II, pyridoxal-phosphate binding site	Binding Site
A [auth C], B [auth D], C [auth A], D [auth E], E [auth B]	IPR015421	Pyridoxal phosphate-dependent transferase, major domain	Homologous Superfamily
A [auth C], B [auth D], C [auth A], D [auth E], E [auth B]	IPR015422	Pyridoxal phosphate-dependent transferase, small domain	Homologous Superfamily
A [auth C], B [auth D], C [auth A], D [auth E], E [auth B]	IPR015424	Pyridoxal phosphate-dependent transferase	Homologous Superfamily
A [auth C], B [auth D], C [auth A], D [auth E], E [auth B]	IPR010961	Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase	Domain
A [auth C], B [auth D], C [auth A], D [auth E], E [auth B]	IPR004839	Aminotransferase, class I/classII, large domain	Domain
A [auth C], B [auth D], C [auth A], D [auth E], E [auth B]	IPR050087	8-amino-7-oxononanoate synthase class-II	Family
F	IPR001917	Aminotransferase, class-II, pyridoxal-phosphate binding site	Binding Site
F	IPR015421	Pyridoxal phosphate-dependent transferase, major domain	Homologous Superfamily
F	IPR015422	Pyridoxal phosphate-dependent transferase, small domain	Homologous Superfamily
F	IPR015424	Pyridoxal phosphate-dependent transferase	Homologous Superfamily
F	IPR010961	Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase	Domain
F	IPR004839	Aminotransferase, class I/classII, large domain	Domain
F	IPR050087	8-amino-7-oxononanoate synthase class-II	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
F	LLP	Parent Component: LYS RESID: AA0119 PSI-MOD : N6-pyridoxal phosphate-L-lysine MOD:00128

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.